Posted 20 November 2004 - 08:50 PM
Posted 22 November 2004 - 06:18 PM
Posted 29 November 2004 - 02:56 PM
Posted 02 December 2004 - 07:23 PM
Posted 07 December 2004 - 03:09 PM
- beautybecomes I highly, highly doubt it was the Accutane. For 2 major reasons. Accutane is a vitanim A derivitive, and unless you have a high sensitivity to vitamin A I doubt you have an alergic reaction to Accutane. Secondly, Accutane is oral. If you were having an alergic reaction to it it would show symptoms in a more inside manner, not external. I guess I have 3, but this is more of a question, did you have this reactoin on your first course of Accutane? If you did I would reconsider my veiws but if you did not I'm pretty sure Accutane has nothing to do with it. Look to your facial products firstly and see if you have changed any products at the onset of this alergic reaction.
Posted 28 December 2004 - 04:09 AM
I notice that there are quite a few people who have been on accutane more than once. It seems to work for a few years after, but comes back. (I am on it myself for a second time)
What is different about those people that have clear skin??? Come on! they have hormones too! And if it's hormones, why didn't my acne clear up when I was one the BC pill??? What makes us acne sufferers different and why can't researchers find a simple cure?
Not one person in my family has this problem but ME. My mom has great skin. WHAT HAPPENED TO ME???
I am on accutane again because that is the only thing that ever worked. Even if it was for just a couple of years at a time. I hate having a crappy complexion. People view bad skin as a reflection of poor health. I also hate it when clear skinned people give you their hygene advice as if you didn't take care of yourself properly. They swear by their creams, soaps, and other topical remedies that don't do CRAP for someone who is truly inflicted with cronic acne.
I drink lots of water. I eat healthy. I work out. I have good hygene. What the hell???!!!
So, Accutane. Here we go again. I'm loading more poison into my body in the hopes that I at least appear healthy on the outside if only for a couple of years at a time. I'm not kidding myself. This stuff is horrible to our bodies. But I've litterally tried everything else.
Posted 31 December 2004 - 07:05 AM
I hope it works for you - keep positive.
Posted 24 January 2005 - 05:20 PM
Isotretinoin is a drug used for the treatment of acne. It is a retinoid, meaning it is derived from Vitamin A and is found naturally in the body, produced by the liver in small quantities. Isotretinoin is sold under many brand names, including Accutane├é┬« and Roaccutane├é┬« by Roche. It is also marketed as Accure├é┬« (Alphapharm), Oratane├é┬« (Douglas Pharmaceuticals), and Isohexal├é┬« (Hexal Australia).
Prior to the development of isotretinoin, the mainstay treatment of severe acne was oral antibiotics such as the tetracyclines and erythromycin. While these drugs have proven efficacy, they worked against only one contributing factor of acne, Propionibacterium acnes bacteria. The antibiotics gradually became less effective over time as more resistant strains of the bacterium became prominent.
An early, effective treatment of acne was high doses of the fat soluble vitamin A. At these dose levels (sometimes 500,000 IU per day) effects such as reduced production of sebum and dry hair could be noticed. However the vitamin also had many other prominent side effects which inhibited its widespread use.
The development of the derivative of retinoic acid, isotretinoin (13-cis-retinoic acid), and its release in 1982 by Hoffmann-La Roche was a great step forward in the treatment of acne. The synthetic compound provided better therapeutic benefit than vitamin A, while also producing less side effects. In February 2002 Roche's patents for isotretinoin expired, there are now many other companies selling cheaper generic versions of the drug.
Today isotretinoin is usually prescribed after other acne treatments have failed to produce results. The treatment of acne usually begins with topicals, moves onto oral antibiotics (or a combination) and finally isotretinoin therapy. This is because other treatments, while less effective than isotretinoin, produce far fewer side effects.
Isotretinoin is available as Accutane├é┬« inside the USA and as Roaccutane├é┬« outside of the USA, both of these brands being produced by Hoffmann-La Roche. It is also available in other brand names around the world.
It is available as 10mg (light pink), 20mg (maroon) and 40mg (yellow) color coded capsules when sold as Accutane├é┬«, and other brands have similar systems.
Isotretinoin is indicated for treatment for a number of dermatological conditions, most commonly acne. It is generally not used as a first-line treatment due to the potential side effects. Antibiotics (such as the tetracyclines) are usually prescribed before isotretinoin.
Severe forms of acne (conglobata, fulminans and nodulocystic) as well as acne that scars can be successfully treated with isotretinoin.
Acne that has not responded to other treatment will usually respond to isotretinoin. Dysmorphobic patients may also be prescribed isotretinoin.
Isotretinoin noticeably reduces the production of sebum and shrinks the sebaceous glands. It stabilises keratinization and prevents comedones from forming. The exact mechanism of action is unknown, however it is known that it alters DNA transcription.
The dose of isotretinoin a patient receives is dependent on their weight and the severity of the condition. Generally it is prescribed from between .5mg/kg/day to 2mg/kg/day, for example a 70kg (155 pounds) person would take from between 35mg to 140mg per day dependant on the severity of their condition.
It should also be noted that some studies have associated remission of the condition with the total dose taken. It is generally advisable to take a dose of greater than 125mg/kg over the entire treatment period to see maximum benefit.
Isotretinoin, when administered orally, is best absorped when taken after a high fat meal, as it has a high level of lipophilicity. In a crossover study, it was found that the peak plasma concentration more than doubled when taken after a high fat meal versus a fasted condition.
Isotretinoin is primarily (99.9%) bound to plasma proteins, mostly albumin.
At least three metabolites have been detected in human plasma after oral administration of isotretinoin. These are 4-oxo-isotretinoin, retinoic acid and 4-oxo-retinoic acid. Isotretinoin also oxidises, irreversibly, to 4-oxo-isotretinoin.
The metabolites of isotretinoin are excreted through both urine and feces. The mean elimination half life for isotretinoin is 21 hours, with a standard deviation from this mean of 8.2 hours.
Vitamin A, in supplement form, should be strictly avoided while undertaking therapy with isotretinoin. It increases the risk of side effects associated with use.
Tetracycline antibiotics, also prescribed for acne, should also be avoided. A significant increase in the risk of pseudotumor cerebri is associated with concurrent use of these drugs.
Isotretinoin has many side effects, listed in the table on the right. The more severe side effects are listed here in more detail.
It is also worth noting that the following side effects can persist, even after discontinuing therapy:
* Alocepia (Hair Loss)
* Decreased night vision
Isotretinoin is a teratogen, it is highly likely that if taken during pregnancy that it will cause birth defects. In the USA isotretinoin is in pregnancy category X. Accutane must be prescribed under a policy that mandates that female patients be placed on two separate, effective forms of birth control . Male patients should be informed of the risk associated with use during pregnancy, emphasising that they should not share the drug, especially with females.
In the U.S. more than 2,000 women have become pregnant while taking the drug between 1982 and 2003, with most pregnancies ending in abortion. About 160 babies with birth defects were born. Doctors normally require two separate methods of birth control for sexually active women taking Accutane and until one month after terminating the drug.
Many studies    have emerged linking isotretinoin to depression. It must however be acknowledged that its primary use is for the treatment of the most severe acne. The possibility that this severe acne is causing the depression is therefore not to be ruled out.
*Hoffmann-La Roche (Makers of (Ro)accutane)
*FDA's Accutane Information Page
*Accutane Action Group (Group of people who suffered continuing side effects from isotretinoin).
*Acne.org (provides a forum on which many people keep diaries on Accutane use)
*Australian Roaccutane Survivors (Similar to AAG above)
*Drugs.com Isotretinoin Information
Elimination half life: 21 hours
Excretion: Feces and Urine
Pregnancy category: X (USA), X (Aus)
Legal status: Prescription
Indicated for: Severe Recalcitrant Nodular Acne
Pregnancy and/or Breast feeding
Hypersensitivity to Isotretinoin
Sensitive to parabens
Teratogenic (Severe birth defects)
Palpitation, Tachycardia, Stroke, Vascular Thrombotic Disease
Ear, nose, and throat:
hearing impairment, tinnitus
corneal opacities, decreased night vision, cataracts, color vision disorder, conjunctivitis, dry eyes, eyelid inflammation, keratitis, optic neuritis, photophobia, visual disturbances
inflammatory bowel disease, hepatitis, pancreatitis, bleeding and inflammation of the gums, colitis, esophagitis/esophageal ulceration, ileitis, nausea
allergic reactions, nemia, thrombocytopenia, neutropenia, agranulocytosis
skeletal hyperostosis, calcification of tendons and ligaments, premature epiphyseal closure, decreases in bone mineral density, arthritis, tendonitis, rhabdomyolysis
pseudotumor cerebri, dizziness, drowsiness, headache, insomnia, lethargy, malaise, nervousness, paresthesias, seizures, stroke, syncope, weakness
suicidal ideation, suicide attempts, suicide, depression, psychosis, aggression, violent behaviors, emotional instability
bronchospasms, respiratory infection, voice alteration
acne fulminans, alopecia, bruising, cheilitis, dry mouth, drynose, dry skin, epistaxis, eruptive xanthomas, flushing, fragility of skin, hair abnormalities, hirsutism, hyperpigmentation, hypopigmentation, infections, nail dystrophy, paronychia, peeling of palms and soles, photoallergic/photosensitizing reactions, pruritus, pyogenic granuloma, rash, sunburn susceptibility
increased, sweating, urticaria, vasculitis, abnormal wound healing
Urogenital and reproductive:
This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Isotretinoin".
Posted 01 February 2005 - 08:42 PM
Posted 12 February 2005 - 02:26 PM
Posted 13 February 2005 - 02:21 AM
Posted 14 February 2005 - 07:51 PM
SO I guess my question is, why do I see all these people saying on these Message Boards that Accutane has absolutely nothing to do with healing red spots? I have just started Accutane, but I just think it would make sense for it to help. I'm starting to think that maybe these people had very large scars and now they have small ones and are just upset that the Accutane didn't take them away completely. So I'm thinking maybe (hopefully!) since my scars are not very large, however I believe they do have a large quantity, but that Accutane will essentially banish them. Am I leaving in a dreamworld when I say this?
For example, like Jenn's Accutane Journal (the first journal Google gives! http://jmhpr.tripod....accutanediary/) she started out incredibly inflamed and then at the end she was not inflamed. Now if I were to start with scars like her 12 week pictures, wouldn't the Accutane decrease that inflamation, just as it did for her week 1 to week 20?
WOW, this was super long and I didn't mean for it to come out making me sound like such a dork! But I just wanted to see if anybody could answer and I wanted to make myself very comprehensible!
Posted 14 February 2005 - 08:27 PM
Posted 16 February 2005 - 05:43 AM
Posted 18 February 2005 - 11:48 PM
can you blame me though?
Posted 19 February 2005 - 08:34 AM
Posted 19 February 2005 - 08:58 AM
Posted 24 February 2005 - 12:21 PM
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