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Justin Time

Accutane: Stunt Growth?

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I am 15 years old, and currently under average height. I am growing fast, and building muscle mass, and I am happy about this. I have moderate acne, and I have tried salycyclic acid, bendroyl hydroxide, murad, nuetrogena, proactive, adapalene, and even apple cider vinegar.

I have heard accutane is like the chemotherapy of acne medications, but I read the thing and it said it may stunt bone growth. I don't care if my skin turns yellow and I have to avoid the sun like a vampire, my main worries in life today are growing taller and becoming clear. Are these things conflicting? Is there anything I'm missing?

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I would look into the studies of accutane- I MEAN see what % of people that kind of side effect had an effect on ( that sounds weird). Then of course- ask your doctor.


"Ancient lovers believed a kiss would literally unite their souls, because the spirit was said to be carried in one's breath."


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I would look into the studies of accutane- I MEAN see what % of people that kind of side effect had an effect on ( that sounds weird). Then of course- ask your doctor.

Currently - all clear!

Maintaining my last Accutane course (10/05-04/06) click here for log

Yasmin on Seasonale schedule

Green Cream lvl 6

Shiseido White Lucent system

(cleanser, and SPF 16 moisturizer (no way, SPF that doesn't sting!?))


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I think it did that to me, and I only took it for 1 month! (I stopped that first time). I was about 14-15 and fairly tall for that age, but then I haven't grown for one fucking centimeter in 2,5 years !!


Took tetracycline for more than a year, got immune to it.

After that I've used BP for 2 months and a week (the regimen for 1 month and 3 weeks), cleared my skin moderately, but was still getting cysts, and wrinkles/red marks/scars would appear from nowhere. Had a shitty looking skin too. Wasn't working so I stopped taking BP, and now I'm on roaccutane.

I'm around the 172.5 lbs (78 kg) right now.

Morning

---------------

Apply moisturizer (Eucerin for dry skins with 5%urea)

Apply chapstick.

Evening

---------------

STOPPED ROACCUTANE THE 22nd OF JUNE 2007 (20mg=>40mg=>80mg=>40mg (the last week))

Wash with Cetaphil cleanser for sensitive skins.

Wait 10 mins

Apply Moisturizer (same as the one I use in the morning)

Apply chapstick


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I think it did that to me, and I only took it for 1 month! (I stopped that first time). I was about 14-15 and fairly tall for that age, but then I haven't grown for one fucking centimeter in 2,5 years !!

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I am 15 years old, and currently under average height. I am growing fast, and building muscle mass, and I am happy about this. I have moderate acne, and I have tried salycyclic acid, bendroyl hydroxide, murad, nuetrogena, proactive, adapalene, and even apple cider vinegar.

I have heard accutane is like the chemotherapy of acne medications, but I read the thing and it said it may stunt bone growth. I don't care if my skin turns yellow and I have to avoid the sun like a vampire, my main worries in life today are growing taller and becoming clear. Are these things conflicting? Is there anything I'm missing?

from Package Insert

Skeletal

Bone Mineral Density

Effects of multiple courses of Accutane on the developing musculoskeletal system

are unknown. There is some evidence that long-term, high-dose, or multiple

9

courses of therapy with isotretinoin have more of an effect than a single course of

therapy on the musculoskeletal system. In an open-label clinical trial (N=217) of a

single course of therapy with Accutane for severe recalcitrant nodular acne, bone

density measurements at several skeletal sites were not significantly decreased

(lumbar spine change >-4% and total hip change >-5%) or were increased in the

majority of patients. One patient had a decrease in lumbar spine bone mineral

density >4% based on unadjusted data. Sixteen (7.9%) patients had decreases in

lumbar spine bone mineral density >4%, and all the other patients (92%) did not

have significant decreases or had increases (adjusted for body mass index). Nine

patients (4.5%) had a decrease in total hip bone mineral density >5% based on

unadjusted data. Twenty-one (10.6%) patients had decreases in total hip bone

mineral density >5%, and all the other patients (89%) did not have significant

decreases or had increases (adjusted for body mass index). Follow-up studies

performed in 8 of the patients with decreased bone mineral density for up to 11

months thereafter demonstrated increasing bone density in 5 patients at the

lumbar spine, while the other 3 patients had lumbar spine bone density

measurements below baseline values. Total hip bone mineral densities remained

below baseline (range 1.6% to 7.6%) in 5 of 8 patients (62.5%).

In a separate open-label extension study of 10 patients, ages 13-18 years, who

started a second course of Accutane 4 months after the first course, two patients

showed a decrease in mean lumbar spine bone mineral density up to 3.25% (see

PRECAUTIONS: Pediatric Use).

Spontaneous reports of osteoporosis, osteopenia, bone fractures, and delayed

healing of bone fractures have been seen in the Accutane population. While

causality to Accutane has not been established, an effect cannot be ruled out.Longer term effects have not been studied. It is important that Accutane be given

at the recommended doses for no longer than the recommended duration.

Hyperostosis

A high prevalence of skeletal hyperostosis was noted in clinical trials for

disorders of keratinization with a mean dose of 2.24 mg/kg/day. Additionally,

skeletal hyperostosis was noted in 6 of 8 patients in a prospective study of

disorders of keratinization.6 Minimal skeletal hyperostosis and calcification of

ligaments and tendons have also been observed by x-ray in prospective studies of

nodular acne patients treated with a single course of therapy at recommended

doses. The skeletal effects of multiple Accutane treatment courses for acne are

unknown.

In a clinical study of 217 pediatric patients (12 to 17 years) with severe

recalcitrant nodular acne, hyperostosis was not observed after 16 to 20 weeks of

treatment with approximately 1 mg/kg/day of Accutane given in two divided

doses. Hyperostosis may require a longer time frame to appear. The clinical

course and significance remain unknown.

10

Premature Epiphyseal Closure

There are spontaneous reports of premature epiphyseal closure in acne patients

receiving recommended doses of Accutane. The effect of multiple courses of

Accutane on epiphyseal closure is unknown.

Vision Impairment

Visual problems should be carefully monitored. All Accutane patients

experiencing visual difficulties should discontinue Accutane treatment and have

an ophthalmological examination (see ADVERSE REACTIONS: Special

Senses).

Corneal Opacities

Corneal opacities have occurred in patients receiving Accutane for acne and more

frequently when higher drug dosages were used in patients with disorders of

keratinization. The corneal opacities that have been observed in clinical trial

patients treated with Accutane have either completely resolved or were resolving

at follow-up 6 to 7 weeks after discontinuation of the drug (see ADVERSE

REACTIONS: Special Senses).

Decreased Night Vision

Decreased night vision has been reported during Accutane therapy and in some

instances the event has persisted after therapy was discontinued. Because the

onset in some patients was sudden, patients should be advised of this potential

problem and warned to be cautious when driving or operating any vehicle at

night.

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I am also very curious to this anyone else have any more info is the concensus that it doesnt stunt growth? I dont remember my doctor warning me about this or reading it on the warnings in the package of medicine?

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The warning on the package indicates only that there have been anecdotal reports of premature growth plate closure. There is no data on how often this happens, and since it hasn't shown up in studies, but has only been reported, it's not possible to know if it would have happened to these people even without Accutane. I wouldn't say that there is a consensus that it doesn't do this, more that it's unknown.


Currently - all clear!

Maintaining my last Accutane course (10/05-04/06) click here for log

Yasmin on Seasonale schedule

Green Cream lvl 6

Shiseido White Lucent system

(cleanser, and SPF 16 moisturizer (no way, SPF that doesn't sting!?))


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I think it did that to me, and I only took it for 1 month! (I stopped that first time). I was about 14-15 and fairly tall for that age, but then I haven't grown for one fucking centimeter in 2,5 years !!

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clinical trials havent shown much of an effect like that. I think what it might be, just to speculate, is more of a side-effect of the side-effects; the physical and mental stress associated with the treatment. For one, a lot of people seem to get depressed while on this drug. People often change their eating habits while depressed. I was always a short guy but to make things worse i stopped growing when i was 15. I had an x-ray done when i was 17 which actually seemed to show some indirect evidence that my growth plates were still active. I think the reason i stopped growing around the age of 15 was actually that i had, basically, stopped eating because i was so stressed out from going on and off of this medication. I wasnt doing it out of any obsession with my weight, i was just so depressed on accutane that i had lost the will to eat. Another factor playing into this was the fact that i was using a ritalin-like ADD pill (a long lasting stimulant called concerta) which tends to curb appetite quite a bit. Then there is the physical stress that accutane puts on the body, bones and joints especially, which probably also has a large effect, though i wouldnt know any specifics. If anything, all of this would be rare and, in some cases, preventable, anyway. I actually know quite a few people who have been on accutane and while none of them seem to have grown too much after having treatment, they havent seemed to have had their growth stunted. Several are quite tall, though they were already near their current height by the time they used accutane. I think that says more about the age that people generally start their accutane treatment than it says about growth stunting. They were all already 16 or 17 by the time they started their treatment and probably only had one or two more inches of growth in them anyway.

and by the way, i would definitely not recommend accutane for somebody who only has moderate acne. Especially if your weight lifting. I broke the cartilage in both of my knees from doing simple squats with a relatively light weight and had physical therapy for 9 MONTHS (i started to heal almost immediately after i had got off the accutane. And also, i had never had even a minor injury in my entire life before i went on accutane.). I happened to respond very poorly to accutane, though many people who get the effects only lightly report joint pains and NO ONE is recommended to put stress on their joints with heavy lifting while on the drug.

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I would be very cautious about taking accutane if you're not happy with your height yet. I'm concerned that the reason there is no evidence that it stunts growth is because it hasn't been specifically studied. I'm guessing the FDA has not required it to be studied because it's not a dangerous or fatal side effect, so the drug company hasn't done it. I wish someone would do the study! I bet the data is already there in doctors offices. On a personal note, I'm fairly sure it stunted my son's growth. He started taking it at 13 in a period of rapid growth, and he stopped growing instantly. He was on it for four months and has been off for eight months now. He has recently grown a very tiny amount, and I'm hoping for the best.

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No, the problem is that the side effect has not shown up in the clinical trials. If it happens it's very rare.

Regarding your son, what supposedly causes stunting is premature growth plate closure. If Accutane had caused his growth plates to close prematurely he would not have grown at all since then. It's very possible that the stress of the course temporarily stopped his growth much like it tends to temporarily stop hair growth, but that's not "stunting."


Currently - all clear!

Maintaining my last Accutane course (10/05-04/06) click here for log

Yasmin on Seasonale schedule

Green Cream lvl 6

Shiseido White Lucent system

(cleanser, and SPF 16 moisturizer (no way, SPF that doesn't sting!?))


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Beentheredonethat, I am very interested in information on clinical trials that actually looked at the issue. I haven't been able to find any. Have you? Thanks for any information.

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Actually believe it or not I grew about half an inch, I have been on Accutane for 1 month so far with a low dose of 20mg/day. I was 5'8.5 when I started and and am now 5'9, I measured this at the gym with thoose fool proof machines were you step inside than bring the top down on your head to get an accurate measurement. I am male, 150lbs and am 22, so growth stunting was not a signifficant problem with me, at 22 I had assumed that I had reached my full height already but was surprised that I grew an extra half inch, maybe there's more to come, to tell you the truth I really don't, height has never been an issue for me, Im not tall but im not a midget either, so I dont really care, im perfectly happy with 5'9.

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Beentheredonethat, I am very interested in information on clinical trials that actually looked at the issue. I haven't been able to find any. Have you? Thanks for any information.

Currently - all clear!

Maintaining my last Accutane course (10/05-04/06) click here for log

Yasmin on Seasonale schedule

Green Cream lvl 6

Shiseido White Lucent system

(cleanser, and SPF 16 moisturizer (no way, SPF that doesn't sting!?))


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