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About alternativista

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  • Birthday 06/07/1965

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  • Location Houston, TX


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  1. Dear alternativista,

    First thank you for your articles from good things. I'm so tired now that I can't read them.. you know I'm spending every day 2 hours to think how can I cure my acne. I had severe acne and  I took many antibiotics since I was kid because I was so sick and my parents didn't have a good life style especially they could have one. Now i went to a dermatoligyst and he gave me antibiotic for 1 year. It transformed my acne into moderate acne but I think it damaged other things from my body.

    Now I'm worring about the things that I asked in this topic

    Would you like to help me ?

    Thank you and best regards

  2. So, i just came across this protein. A quick searcg finds quite a few studies. So I googled how to down-regulate zonulin. The article below says " Splenda is suspected as a stimulator of zonulin along with heavy metals, stress, and most likely other triggers not yet discovered. Gluten is one of the many proteins that seems to be involved in inflammation and autoimmune problems when leaked out of the gut. " We've known that food intolerences often develop due to stress. Then it says something about treating patients with supplements to down regulate zonulin, but doesn't name them, Here are more articles. Aparently probiotics are one method. There's this article about zinc Carnosine ( ZnC ), which is an artificially created "nutriceutical". We know zinc benefits acne. Carnosine is taken by body builders & for antiaging for reasons I don't really remember right now. Muscle recovery I think & anti-inflammatory/anit-oxidant. "carnosine is a dipeptide (comprising β‐alanine andl‐histidine) that is naturally present in long‐living cells such as muscle and nerves, where, among other actions, it probably has a role as an antioxidant." I took if for a little while. I also took b-alanine to both produce carnosine & be an anti-histamine. But the researchers only state it would be interesting to examine it's impact on zonulin.
  3. A healthy food I cannot make myself eat is...

    I love kale. The only healthy thing I'm not into that I can think of right now is fermented vegetables like saurkraut, kimchi, etc. Especially kimchi. I do like saurkraut, but only a little bit along with the type of food/meal it's traditionally served with. And i rarely eat those things. I even made a Central American version of saurkraut that I like, but still, I don't eat food/meals that it would go with. (It's traditionally served with Pupusas, which I like but wouldn't eat often. There's no place to get them near me. I made them once,) I don't like olives in food like pasta sauce, in salads, pizza. I don't like that kind of flavor contrasting with the other food Shrimp aren't crunchy.
  4. Better Grains and grain substitutes

    Bumping so it doesn't get archived. And because someone mentioned that the recipe thread links were broken.
  5. Dessert Recipes and Ideas

    Bump, so it doesn't get archived. And surely you all have new recipes & ideas..
  6. Exp Dermatol. 2013 May;22(5):311-5. doi: 10.1111/exd.12142. Potential role of FoxO1 and mTORC1 in the pathogenesis of Western diet-induced acne. Melnik BC1, Zouboulis CC. Author information Abstract Acne in adolescents of developed countries is an epidemic skin disease and has currently been linked to the Western diet (WD). It is the intention of this viewpoint to discuss the possible impact of WD-mediated nutrient signalling in the pathogenesis of acne. High glycaemic load and dairy protein consumption both increase insulin/insulin-like growth factor-1 (IGF-1) signalling (IIS) that is superimposed on elevated IGF-1 signalling of puberty. The cell's nutritional status is primarily sensed by the forkhead box transcription factor O1 (FoxO1) and the serine/threonine kinase mammalian target of rapamycin complex 1 (mTORC1). Increased IIS extrudes FoxO1 into the cytoplasm, whereas nuclear FoxO1 suppresses hepatic IGF-1 synthesis and thus impairs somatic growth. FoxO1 attenuates androgen signalling, interacts with regulatory proteins important for sebaceous lipogenesis, regulates the activity of innate and adaptive immunity, antagonizes oxidative stress and most importantly functions as a rheostat of mTORC1, the master regulator of cell growth, proliferation and metabolic homoeostasis. Thus, FoxO1 links nutrient availability to mTORC1-driven processes: increased protein and lipid synthesis, cell proliferation, cell differentiation including hyperproliferation of acroinfundibular keratinocytes, sebaceous gland hyperplasia, increased sebaceous lipogenesis, insulin resistance and increased body mass index. Enhanced androgen, TNF-α and IGF-1 signalling due to genetic polymorphisms promoting the risk of acne all converge in mTORC1 activation, which is further enhanced by nutrient signalling of WD. Deeper insights into the molecular interplay of FoxO1/mTORC1-mediated nutrient signalling are thus of critical importance to understand the impact of WD on the promotion of epidemic acne and more serious mTORC1-driven diseases of civilization. © 2013 John Wiley & Sons A/S. Dermatoendocrinol. 2012 Jan 1;4(1):20-32. doi: 10.4161/derm.19828. Dietary intervention in acne: Attenuation of increased mTORC1 signaling promoted by Western diet. Melnik B. Author information Abstract The purpose of this paper is to highlight the endocrine signaling of Western diet, a fundamental environmental factor involved in the pathogenesis of epidemic acne. Western nutrition is characterized by high calorie uptake, high glycemic load, high fat and meat intake, as well as increased consumption of insulin- and IGF-1-level elevating dairy proteins. Metabolic signals of Western diet are sensed by the nutrient-sensitive kinase, mammalian target of rapamycin complex 1 (mTORC1), which integrates signals of cellular energy, growth factors (insulin, IGF-1) and protein-derived signals, predominantly leucine, provided in high amounts by milk proteins and meat. mTORC1 activates SREBP, the master transcription factor of lipogenesis. Leucine stimulates mTORC1-SREBP signaling and leucine is directly converted by sebocytes into fatty acids and sterols for sebaceous lipid synthesis. Over-activated mTORC1 increases androgen hormone secretion and most likely amplifies androgen-driven mTORC1 signaling of sebaceous follicles. Testosterone directly activates mTORC1. Future research should investigate the effects of isotretinoin on sebocyte mTORC1 activity. It is conceivable that isotretinoin may downregulate mTORC1 in sebocytes by upregulation of nuclear levels of FoxO1. The role of Western diet in acne can only be fully appreciated when all stimulatory inputs for maximal mTORC1 activation, i.e., glucose, insulin, IGF-1 and leucine, are adequately considered. Epidemic acne has to be recognized as an mTORC1-driven disease of civilization like obesity, type 2 diabetes, cancer and neurodegenerative diseases. These new insights into Western diet-mediated mTORC1-hyperactivity provide a rational basis for dietary intervention in acne by attenuating mTORC1 signaling by reducing (1) total energy intake, (2) hyperglycemic carbohydrates, (3) insulinotropic dairy proteins and (4) leucine-rich meat and dairy proteins. The necessary dietary changes are opposed to the evolution of industrialized food and fast food distribution of Westernized countries. An attenuation of mTORC1 signaling is only possible by increasing the consumption of vegetables and fruit, the major components of vegan or Paleolithic diets. The dermatologist bears a tremendous responsibility for his young acne patients who should be advised to modify their dietary habits in order to reduce activating stimuli of mTORC1, not only to improve acne but to prevent the harmful and expensive march to other mTORC1-related chronic diseases later in life. KEYWORDS: FoxO, IGF-1, Western diet, acne, androgen, insulin, leucine, mTORC1, nutrition, prevention Exp Dermatol. 2013 Jul;22(7):505-6. doi: 10.1111/exd.12180. Turning acne on/off via mTORC1. Danby FW. Author information Abstract Over the past 10 years, the increase in comprehension of the mechanisms behind acne has been truly exponential. Starting with the ethnological work of Cordain, accelerated by the epidemiological work of Adebamowo, supported by the clinical trials of Smith and Mann, Kwon, DiLandro and others, the interface of diet and acne is coming into focus. Melnik now presents an exceptional pair of papers that illustrate for dermatologists what translational research is all about. The Western diet, the role of dairy, FoxO1 and mTORC1, the interplay of agonists and antagonists, therapeutics present and future - the jigsaw puzzle is coming together. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Full article: http://www.landesbio..._full_text=true http://www.lipidworl.../content/8/1/25 These papers on mTor & acne are excellent summaries of all the known factors involved in acne formation and most of the research into cause and intervention from big pharma like isotretinoin, BP and metformin to EGCG and resveraterol. And of course diet, especially the western diet. And I wish to point out that they cite over one hundred scientific studies into these factors and how nutrients and diet habits affect those factors and thus acne. And yet people keep claiming there's no scientific evidence that diet affects acne. I guess it's like climate change deniers. No amount of evidence will change their minds.
  7. Good Things For The Many Factors That Lead To Acne

    Yes. Every time they update the server software links get broken & other weirdness happens. I used to fix them, but don't haven't had time lately. Sorry about that. Most of the content i.e. the many ways diet affects acne: inflammation, liver, thyroid, sebum quality, food intolerance, etc is in the first couple of pages. So you can just scroll through. That's too bad about the Food & recipe thread. It's been archived so can't be fixed. But many were created by me & you can find them by looking for my topics . And searches might find the others. The only thing that ever worked for me is oil cleansing.
  8. Hi alternativista,

    I've read some of your posts on here and was asking myself what the meaning of "nutrient dense" was across the posts I've looked at:

    > "What's required for clear skin and health is real, whole nutrient dense foods in low to moderate glycemic impacting meals, drinks and snacks that consist of more anti-inflammatory foods than inflamatory, and that doesn't include anything you have an intolerance for."

    By nutrient dense, are you talking about having a high amount of macronutrients (proteins, carbohydrates, fats...) or some other kind of nutrient category I may be missing?

    I notice you haven't visited this site in a while. I'll keep looking around, however.

    1. alternativista

      Macro & micro nutrients.   As opposed to food that is mostly empty calories.  a whole food vs a heavily processed food.    Raw, fermented or quickly sauteed vs deep fried, or over cooked until nutrients are destroyed.  A sweet potato vs a slice of bread or pasta.

  9. hello. would you recommend saw palmetto for me to treat acne? im male. 26 years old. i saw some of your posts. so i thought to give you a message :) thanks in advance!