Kynarr

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About Kynarr

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  • Gender Male
  • Location Quebec, Canada
  • Interests I'm looking to fix my inability to gain muscle and keep an optimal body composition, hypersomnia + lack of will to live, dry face skin and eyes, chronic rhinitis, easily inflamed and aching joints, IBS, constant bloating, low libido, brain fog, etc. All the classic post Accutane symptoms.

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  1. I had a single mercury filling that I've had since I was 10 or so. I got it removed 2 months ago, and replaced it with the composites they now apply instead. I feel good mentally for having removed something which I know is toxic, and I can now freely detoxify and use clay and stuff without being worried about *pulling* mercury from my month. However, I don't feel physically better. Mercury fillings are not good, but I highly doubt that they have any relation to Accutane. If you have one, just find some holistic dentistry place and have it removed. Contrary to Accutane, this is easily fixed. - I've read the vit C toxicity study. I can't be assed finding pro vit C sources, but everything i've read points to vit C being insanely useful, especially as we're pretty much the only mammal not to produce vit C. We depend on external vit C to help detoxify, and with how much crap we need to detoxify from, I can't picture vit C being bad for us. I'm talking 2-3g a day here. I don't know about 100g+ IV injections of vit C, haven't tried them, but vit C is super useful, if ONLY for collagen production; post Accutane skin needs it. The whole methylfolate / folic acid / b12 subject is confusing to me. I don't fully grasp it. All I know is that my B12 has always been in the upper range in my blood test results (B12 518 pmol/L (ref 95-575)), from 2014 to today, so I've never bothered looking deeper into it. Educate me if I'm being naive please. @tanedout I've send him a message. We'll see what gives. @Washer I forgot to specify I also take selenium and pink Himalayan salt. I've never felt the need to supplement B vitamins as I eat Paleo with plenty of meat. I've tried supplementing B1 and B6 in the past and I never cared for it. The first supplement I took, way before getting so deep down the rabbit hole, was B6, for seretonin production. A natural anti-depressant if you'd like. The doses were unhealthy though, so I stopped a couple years back. Niacin (B3) destroys me. Insane flushes. I've tried on many occasions. Doesn't seem to bring any improvement. I've looked into Boron before and I definitely find it interesting, especially for its T levels improvements. It's in my list, though I'm personally through trying to fix this naturally. I take enough supplements as it is. @guitarman01 Maybe buy Ketone strips and test it out for yourself over a few days? Do you eat carbs? Are you following a ketogenic diet? Many things impact ketone levels. It's likely dietary. - For those who are planning to get on TRT, here are the comments from a knowledgeable guy on my thread on the Buleltproof forums. Consider avoiding Androgel. I know it's not doing much for me at least: Jason Hooper ✭✭✭ March 31 Coincidently, I have spoken with several people who were on TRT since my last post in this thread. All of them started out on androgel and it didn't work for any of them. They all switched to an injectable form and it improved their test levels. I thought testosterone undecanoate would be a good option because the injection frequency is the lowest of all trt medications, however most of the people I talked to are on cypionate (one is on enanthate).
  2. I've been on Androgel for a bit over two months now. Here are the hormone results from March 23rd. Testosterone is up slightly to 549 (19). SHBG is down to 40. Estradiol is down to 73. I'll suppose that my E is down due to taking 500mg Calcium D-Glucarate every evening. It is a slight improvement, but overall it IS an improvement. My shape has improved a little bit. I'm a bit more awake, certainly more aggressive and able to do things. It is just not what I was looking for though. At 25, keeping myself healthy, supplementing Testosterone... 549 T is a joke. Most importantly, I don't feel right. I've read The Definitive Testosterone Replacement Therapy, and will be following its guidelines and switch to injections asap. I want to start with Undecanoate and eventually take Propionate once I'm used to injections. - @tanedout I'm not up to date on methylation pathways and stuff. I haven't knowingly taken any supplement that I believe would help with this. I don't know about methylfolate. I still take 60mg+ Iodine everyday with its cofactors magnesium, vit c, vit k2. I tried zinc. The first time I felt like absolutely crap, the other times I don't feel it did anything. I don't feel like Creatine ever really did much for me except make me piss a lot. My CYP2D6 is my only -/- detox pathway. Am I right to believe it might not have been like this before Accutane? Or is specifically the fact that it was already -/-, which prevent Accutane from being eliminated/flushed, therefore causing toxicity in excess? Man, my head is spinning.
  3. Here are mine. I had already posted them but I don't think they were taken into account for what we're looking right now. I definitely hold the belief that the reason we are permanently affected while many aren't, has to do with genes and methylation pathways. Gene & Variation rsID Alleles Result COMT V158M rs4680 AG +/- COMT H62H rs4633 CT +/- COMT P199P rs769224 GG -/- VDR Bsm rs1544410 CT +/- VDR Taq rs731236 AG +/- MAO-A R297R rs6323 TT +/+ ACAT1-02 rs3741049 GG -/- MTHFR C677T rs1801133 GG -/- MTHFR 03 P39P rs2066470 GG -/- MTHFR A1298C rs1801131 TT -/- MTR A2756G rs1805087 AA -/- MTRR A66G rs1801394 AG +/- MTRR H595Y rs10380 __ no call MTRR K350A rs162036 AA -/- MTRR R415T rs2287780 __ no call MTRR A664A rs1802059 AG +/- BHMT-02 rs567754 TT +/+ BHMT-04 rs617219 __ no call BHMT-08 rs651852 TT +/+ AHCY-01 rs819147 TT -/- AHCY-02 rs819134 __ no call AHCY-19 rs819171 TT -/- CBS C699T rs234706 AA +/+ CBS A360A rs1801181 -- no call CBS N212N rs2298758 __ no call SHMT1 C1420T rs1979277 __ no call Gene & Variation rsID Alleles Result CYP1A1*2C A4889G rs1048943 TT -/- CYP1A1 m3 T3205C rs4986883 TT -/- CYP1A1 C2453A rs1799814 GG -/- CYP1A2 164A>C rs762551 AC +/- CYP1B1 L432V rs1056836 CG +/- CYP1B1 N453S rs1800440 CT +/- CYP1B1 R48G rs10012 CG +/- CYP2A6*2 1799T>A rs1801272 AA -/- CYP2A6*20 rs28399444 II -/- CYP2C9*2 C430T rs1799853 CC -/- CYP2C9*3 A1075C rs1057910 AA -/- CYP2C19*17 rs12248560 CT +/- CYP2D6 S486T rs1135840 GG +/+ CYP2D6 100C>T rs1065852 GG -/- CYP2D6 2850C>T rs16947 AG +/- CYP2E1*1B 9896C>G rs2070676 CC -/- CYP2E1*1B 10023G>A rs55897648 GG -/- CYP2E1*4 4768G>A rs6413419 GG -/- CYP3A4*1B rs2740574 TT -/- CYP3A4*2 S222P rs55785340 AA -/- CYP3A4*3 M445T rs4986910 AA -/- CYP3A4*16 T185S rs12721627 GG -/- GSTP1 I105V rs1695 AA -/- GSTP1 A114V rs1138272 CC -/- SOD2 A16V rs4880 AG +/- NAT1 R187Q rs4986782 GG -/- NAT1 R64W rs1805158 CC -/- NAT2 I114T rs1801280 CT +/- NAT2 R197Q rs1799930 AG +/- NAT2 G286E rs1799931 GG -/- NAT2 R64Q rs1801279 GG -/- NAT2 K268R rs1208 AG +/- Gene Result GSTT1 Present
  4. A definite yes for Iodine. Too many hormonal and glandular correlations to Accutane to pass on it. Look, if you've been on Accutane, I just about guarantee your LH/FSH signaling (and therefore Testosterone too) is fried. Your pituitary's fucked. So you better get on Iodine and MAYBE de-calcify a bit from other halogens. I've been taking up to 100mg daily with no sides to speak of, besides vivid dreams/inability to sleep. I view this as a positive though. One MUST stress on the importance of taking Iodine with its co-factors, though: https://docs.google.com/document/d/1t_6oprpjmDCMqwCXP_6BMf0Mbr9DivmOSALeJTjReuY/edit I tried 50mg Zinc a second time today. No dryness this time around. I feel just fine. I'm not sure what it was with the first time I tried it, but I'm always curious to briefly experiment with 5-ARIs. - In regards to TRT, today marks 2 months for me. Getting my hormones checked next week. I feel pretty good mentally. Physically, I'm unsure. My joints are much better. It's much easier for me to walk, do yoga, workout, lift heavy stuff, squat. I definitely gained some muscle, though this is not yet a reference as going on TRT mentally made me crash (no fun to be there at 25yo) and I haven't gone to the gym very consistently. That's absolutely my fault, and I'm getting back on track gym/diet wise and I hope to fully benefit from TRT in that sense, very soon. Libido.. interestingly, nothing to speak about. Like, nothing. I think it's worse since beginning TRT. I'm much more aggressive, much more sharp, much more able to just do stuff and accomplish my daily goals. I no longer nap. I can live on little sleep where as I used to require 10h+ everyday. Dryness wise... I'll suggest it has very, very slightly improved. Chronic rhinitis is a bit better. Face skin still pretty dry. The rest of my skin is pretty darn smooth. My hair feels a bit more brittle. Tough to explain, but it's not in a bad way. Its texture has just changed a bit. My eyes are dry as usual. IBS has improved. My stomach tends to not be as big and inflamed for a skinny athletic person. Foods haven't been hurting me as much. Toilet-wise.. it's been worse, but is it TRT? I'm thinking it might be the Magnesium (malate/oxide) I had been taking so far. TRT supposedly builds up over time. I'm not taking injections yet, and I understand Androgel might be poorly absorbed by some. I will likely change the administration route upon having my hormone results. I don't believe my T levels are much higher, but I remain very positive that TRT brings about permanent improvements to many issues caused by Accutane. I've been a bit down lately. Some things sometimes are tougher to accept than others, but I'm back, feeling better, and more than ever prepared to cure myself and get the life I want. Summing up, here's my life currently: Daily Supplements 5g androgel 60mg+ Iodine 2g vit C 2000mg vit K2 200-400mg Magnesium 200mg Selenium 500mg Calcium-D-Glucarate 400 IU vit E 4k IU vit D 250mg Rhodiola (every so often, energy/focus boost) 500mg Phenibut (once a week or so, acts much like alcohol replacement) Some Nootropics here and there for fun. After a chaotic restaurant discovery month, back to a strict paleo/bulleproof diet. Very clean. Many veggies, much healthy fat and high quality proteins. Daily Yoga, Meditation, Acupressure. A/B/C workouts over 8/9 days doing SDeadlift, Squats, Bench, Pullups, Pushups. Walking 1h+ a day outside. Very strict nofap hard-mode.
  5. Hey guys, I'll take some time to report back on TRT this week. So far so good. I'm not sure it's the cure I was looking for, but mood wise, I feel like there are improvements. I'm probably getting my hormone levels checked this week, so within a couple days I'll know how its changed since. Quick question regarding Zinc, as it's always been confusing to me that we'd supplement it when it's a 5-ARI. I finally bought some yesterday, and took 50mg zinc citrate before bed. I feel very odd mentally. Extremely thirsty. Face skin is burning with how dry it is. No libido, at all. Is this common for you guys when taking Zinc? It feels horrible. I'm used to drinking like 20 glasses of water a day... but I'm just.. so thirsty right now...
  6. It seems you don't know what you don't know. You should seek to fix this. You can safely ingest 100mg iodine a day without a single issue.
  7. There's this book I've also yet to find online for a reasonable price: https://www.amazon.com/Retinoic-Acid-Structure-Mechanisms-Microbiology/dp/1621005976 TRT costs me 35$ here in Canada. I recommend the following book, as it covers a lot that this threads discusses, including SERMs, AIs, Vit D, Zinc.. you name it. Most everything we discuss here, TRT implicates. I would like to see other low T people try TRT, as it's the next logical step. SERMs and AIs have too many potential risks. It is better to try TRT first. This book helps understand why it's not so bad at all. https://www.amazon.com/Definitive-Testosterone-Replacement-Therapy-MANual/dp/B01N2IDCNH
  8. That video with 6k views? From an unknown youtube channel? That doesn't cite any source? Have you tried what this video proposes? I have. My very first idea was Vit A toxicity. I've since accepted it's not so simple. I welcome any attempt to detoxify. Not just from Accutane, but from everything. EVERYONE should do more to help our bodies detoxify and remain healthy, but if you think all it takes is to supplement a couple naturals things and your bile flow will restart and flush excess vit A... man, you need to re-read this thread from page one. I've taken over 150g of Calcium D Glucarate + Glucuronolactonoe over the past couple months. You know what it did? Nothing. I might have felt better on X Y Z instance while supplementing, but ultimately, here I am today, same as before. I've tried plenty of other supplements and vitamins suggested here. Again; nothing. As far as anyone can tell right now, we're dealing with hormones issues. This has been very well established, yet nobody here seems to be getting their hormones checked and fixed. I find this highly questionable. Whether it's from a negative feedback loop, plain impaired ability to produce hormones due to glands having been wrecked by too much Retinoic Acid (and I fiercely maintain my GET YOUR PITUITARY CHECKED idea), or T receptors being fried, remains a guess. But please, after 20 years, you should know better than everyone here that your issue is NOT vit A toxicity. No longer at least.
  9. Met with the Neurologist today. Over two years on a waiting list only to be prescribed Naproxen. What a fucking joke. I'll have to meet with an Endocrinologist if I want to get a scan to verify my Pituitary. This neurologist had no use for further testing as my ophthalmic migraines are presumably genetic, therefore the only *cure* is to take pills everyday for the rest of my life; no thank you. My aggressiveness has been ramping up in the past week, which I'd like to associate with increased T. I'll presume it's positive, but I will remain skeptic as long as I don't have blood results showing proper T levels, and most especially so long as I don't feel *normal* physically and mentally. I've had a couple short moments of absolute clarity since beginning TRT, but as far as I'm concerned, my T receptors might be so fried that my body doesn't even know what to make of the T I'm giving it. Time will tell. Again, strength has definitely improved, but my face is still dry. I'd think more T would solve this, but I guess not. My libido, oddly, has worsened. I just don't feel like having sex right now. I'll look into testing my telomere length soon. Ehohel's and John86's testing gives me good indication that the telomere length of any Accutane user is significantly shortened. This non Accutane user is getting retested sometimes this month, we'll see if Epitalon works mid-term soon enough: https://www.reddit.com/user/telomerotica I'm not sure about CLA, but in case you guys are still onto the *vit A toxicity* theory, I'd tell you not to bother. Something somehow went wrong, but Accutane is long gone from our system. We might have more stored vit A than most people, but I highly doubt that's the problem.
  10. Will do. I have been having ophthalmic migraines since more or less the time I began Accutane. Not quite sure if it was a month before or after beginning treatment. I'll try to obtain the history to see whether it's correlated or not. I've been having many this year so far, it's becoming difficult to maintain a normal life when I can't see crap half the time and my head just hurts non stop.
  11. Little update on my 15th day of TRT. I've finally obtained my Dec 2016 E2 result; 146 pmol/L, from 84 in june. Something I did between June and Dec lowered my total T (505 to 434), and almost doubled my E2. Might be some remnants of MK-2866. My next blood test will be mid-march, so we'll get to know how Androgel helps me. I'll be taking 1g of CdG daily this month to maybe help keep my E2 in check, along with usual supplements such as vit C and vit D, but nothing else that would strongly affect my hormones. I think I'm doing better, but nothing much to write home about. Mentally I feel just fine, and physically not any different than usual. Libido hasn't improved at all, if anything it might be lower. I've gained ~6 pounds over the past two weeks and am effectively up to 152 from ~135 3 months back. Strength has definitely increased and I look in better shape. People started commenting on me looking in shape just one week into TRT. Odd. I maintain some hope that this is it. I understand it takes a couple weeks to fully take effect so I'll just be patient for now. I met the andrologist a second time this Monday and she showed me the door after 2 minutes. Did not care to discuss, just wanted to be sure I wasn't dying. I obtained the contact to what appears to be the most knowledgeable Endocrinologist locally. It's private so I'll have to pay, but I'll get in touch with him ASAP. I've obtained a meeting with a neurologist this Friday. I will request for a CT Scan and verify how my pituitary gland looks.