sorry i dont have time to read this whole thread, but i just wanted to share some tips i have for green smoothies:
pears work best for me... ive tried apples and the texture was too watery and way too sweet.
use parsley.... parsley makes the taste of the green smoothie very nice, no matter what other greens you include. parsley is very pleasant on its own, and seems to over-power the not-so-pleasant taste of kale and dandelion greens, etc.
my typical green smoothie:
2 medium-size pears large handful of parsley medium handful of dandelion greens medium handful of kale (one large leaf of the lacianato kind) 1 cup of water ------> blend to a smoothie
make sure to chew as you drink it... it adds salivary enzymes, and breaks apart more cells from the greens to release all their nutrients.
to me, toxins means environmental pollutants (absorbed through air, food, water, skin contact), plus your own inflammatory mediators, cytokines, free radicals, pro-inflammatory prostaglandins, complement, and excitotoxins (glutamate).
all these chemicals lead to oxidative stress and chronic inflammation within the body and skin. increased inflammation causes hyper-proliferation of sebocytes and keratinocytes leading to more acne.
sorry, i havent had much time to look at this stuff...
bryan, im guessing you already saw this initial study on MK-386: http://jcem.endojournals.org/cgi/content/full/82/5/1373
they found that "In conclusion, MK-386 is a selective 5R1 inhibitor in man and is associated with a substantial suppression of sebum DHT without an influence on semen DHT".
but the abstract you posted doesnt mention MK-386 so are you sure they used this drug in the study? (for some reason i couldnt get access to the full text through my school)
in any case, it doesnt surprise me that the 5a-reductase type 1 inhibitor didnt improve acne. it just points out that acne is multifactorial and is not easily treated with a purified (synthetic?) substance (as all diseases should not be treated with a purified substance). it would be interesting to see if the drug actually lowered sebum production and still didnt improve acne. if it didnt even lower sebum production, that would just highlight the fact that sebum production is influenced by a variety of factors.
im glad you posted the study... its prompted me to start learning more about how androgens affect acne, and sebum production.
Bryan can you point me to that study please. If legit, it would certainly contradict the marketing efforts of a number of acne-product companies out there... and i think the literature often cites 5-alpha reductase inhibition as lowering sebum production.
LabGirl, thanks for clarifying the linoleate/linoleic acid thing... i've taken a buttload of chemistry courses and probably should have known that... but i hate chemistry, lol!... i mean its cool on the surface, but all the nomencalture, and learning all the diff reactions in ochem was a pain... Yeah, your're probably better off finding a research opportunity nearby... im sure it was nice to get that offer though. i dont think i could stand working in a lab all day so kudos to all the researchers out there.
hehe, we're just a bunch of acne geeks.
DrNick, this would be a great hypothesis for a study... and maybe there has already been a study on this... or atleast an epidemiological study on fatty acid intake and acne.
You would also have to consider omega ratios and all that jive to make sure the increased linoleic is actually used by the body.
Great info, thanks LabGirl. And congrats on the fellowship offer, do you think you'll take it?
I have a few ?s I hope you can help with.
Where and how is linoleate produced from linoleic acid?
Why does a lack of linoleate induce hyperkeratosis in the cells of the follicular epithelium? Does linoleate have an inhibitory effect on keratin production by these cells and how does the signaling occur? Or do the chemicals that take the place of the decreased linoleate have a pro-keratinization affect?
What role do microbial (mainly P. acnes) lipases play in all this?
I often read that P. acnes lipases break down triglycerides in sebum into free fatty acids, which then irritate the cells of the follicular wall. But what exactly does irritation mean and why do the free fatty acids cause the irritation? Also, how exactly do the free fatty acids interact with the follicular wall cells?
thanks for the tip ross, im not really in the mood to buy any supplements at the moment, i just dropped painful amounts of money on PD, fish oil, and a shower filter (but i did score on the filter - 25 bucks for a handheld on ebay).
i think i'll try to eat more foods with high chromium values like broccoli.
you can get the straight skinny on chromium right here: http://lpi.oregonstate.edu/infocenter/minerals/chromium/