Have you ever had acne clear in the summer then come back in the fall? Do you live in the northern hemisphere? I just had one of the clearest skin summers of my life, I mean no acne at all and now it's coming back with vengeance as soon as temperatures started going down. I've had cystic acne since I was 14 and now I am in my late thirty's but it has calmed down quite a bit since my teen years. I still feel self conscience when I go to the beach and have to take off my shirt because I am darker skinned so I have horrible hyper pigmentation on my back. This year I said screw it I am going to lay in the sun and burn those scars on my back. Well haha being darker skinned and no sunblock for the first time in my life I burned by back lol. But something interesting happened, my skin after that day completely cleared up! I mean my whole body and face not just my back! I should also mention that I was outside alot after that too tending my masive yard. Fast forward to today, working at the office being indoors most of the time because it is cold outside and started suffering with bouts of depression and sebaceous cysts! A couple months ago I saw a few forum and blog entries about how people were clearing their skin with Vitamin D3. I had tried Vitamin D3 before and it made my cystic acne worse so of course I counted as another vitamin that didn't work. I kept thinking about how my skin was clear in the summer and I was eating what ever I wanted, even ice cream! Now if I eat ice cream I am guaranteed a cyst that same day. So I found a book called the "The Miraculous Results of Extremely High Doses of Vitamin D3" and through reading it the author said after high doses if Vitamin D3 a sebaceous cyst he had for 5 years disappeared! Now a lightbulb went off. So I was taking 5000 UI but upped it to 10,000 UI for a week. Didn't really do anything until I upped it to 20,000 UI and my normally bucket of oil skin was a lot less oily by the afternoon! But I got scared because I havent had any D3 tests yet and dropped back down to 10,000 UI. I stayed on this for a few weeks and my face started to look way better but I would still get the occasional cyst. My skin that was bumpy from all the overactive sebaceous glands started to become more smooth. Then I found these articles: https://www.medicaljournals.se/acta/content/html/10.2340/00015555-2525 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708967/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580068/
So according to this research paper, extra Vitamin D3 seems to slowdown sebum production. One of the interesting observations in this article is that it also induces autophagy. This means that Vitamin D3 can cause the sebaceous gland to rebuild itself! Very intriguing! Other articles show the relationship between low vitamin D3 status and severity of acne. You are welcome to go to PubMed and do your own research as there is a lot of good information there. Disclaimer: I do not suggest anyone do what I am doing unless they are consulting a doctor for advice.
So now daily I am taking 20,000UI of dry vitamin D3 and 360mcg of Vitamin K2 (M7) to both try to slowdown sebum production, reduce inflamation, move calcium around so it goes where it needs to go, and rebuild my sebaceous glands. 1000mg of vitamin C and 90mg of zinc picolinate (which helped a little on it's own) to aid in remodeling my skin cells and hopefully decrease scars. And since I am taking vitamin D3, it uses magnesium to convert to the active form of vitamin D3 so I also rub on 400-600mg of magnesium oil. I should note that I am also taking 30mg of p5p to treat my self diagnosed Pyroluria. I have also resumed taking claritin as it seems to help with my inflammation (and my allergies).
Very important notes: you MUST take vitamin K2 with vitamin D3 to prevent toxicity! Also the vitamin K2 will remove excess calcium from you blood and soft tissues including skin and put it into your bones. Timing of taking the supplements is also important for example, take D3 in the morning as it will keep you up at night if take it too late and take magnesium only at night unless you want to be sleepy all day.
One last thing, I will eventually get tested for my Vitamin D3 levels but for now will use my skin as a feedback mechanism to reduce or increase my dosage. Once I clear the last cyst that I have on my face, I will drop my zinc dosage to 30mg a day and only take it at night before bed on an empty stomach.