• Content count

  • Joined

  • Last visited

Community Reputation

43 Good

About tanedout

Recent Profile Visitors

1,067 profile views
  1. Been looking into dosages for taurine used in the treatment of liver injury, and in the following study used 6 grams per day (2 grams x 3 per day). After 3 months serum markers of liver damage, as well as markers of oxidative stress, decreased significantly, as did their elevated levels of cholesterol and triglycerides. http://www.ncbi.nlm.nih.gov/pubmed/17690950 Sounds quite promising, and considering there are studies showing benefits to other things which many of us suffer as 'tane sides (such as tinnitus and loss of night vision), as TTH2014 has already mentioned, it would seem to add weight to the theory that we potentially suffer from a taurine deficiency. Good to see numerous others are giving this a go, so be interesting to see if anyone notices any results in a few months!
  2. Decided to jump on the taurine bandwagon with so many promising studies out there, so I'll update if I get any results.  Currently taking 1g per day (2 x 500mg), but I'll up this to at least 2-3g. Sounds like you'd need a pretty serious amount to encounter any toxicity issues. A single Redbull contains 1g and some other energy drinks contain 2g per can after all. One thing I have noticed since starting is aching thigh muscles. Might be unrelated but it's unusual for me, feels like I've run a marathon on hit the gym massively, but I haven't. Bit weird.  I had restarted on the Tudca (3 x 200mg daily), but started get aches in my liver again, as I did towards the end of my 4-5 week stint on that. Nothing intense, but going to hold off that for the moment.
  3. Half a teaspoon will be about 1 gram.  I've just got some taurine powder and it says on the back 1 gram is approx 1/6 of a tablespoon, and generally 1 teaspoon is considered to be about 1/3 of a tablespoon, so 1/2 a teaspoon will be about 1 gram!  I'm going to restart the tudca later this week, and I'm planning to add taurine to the regime. I'm particularly interested in using night vision as a gauge as to whether it's having an effect, as my night vision post tane is basically zero, so even a slight improvement will be noticeable. Been thinking about the high doses of natural vitamin A people have been trying (i.e. as opposed to synthetic vit A like isotretinoin) and I've read somewhere before that RSO (rick simpson oil) is very high in vitamin A as it's essentially pretty much just concentrated 'leafy greens' (most of the dietary fibre and water content removed). There are 3 documented recoveries on this thread from people taking RSO, one of which also involved taking cod-liver oil, so maybe the Vit A is potentially overlooked factor in these. Taking tudca/taurine along with a fairly high intake of natural vitamin A is something I'll consider trying.   
  4. Excellent finds TTH2014! Particularly about taurine playing such an important part in night vision. I'd not read this before (or may have just overlooked it), but it gives me more weight to a lot of your recent theory. I'm going to get hold of some to supplement. Interestingly one of the most effective things I've found for tane sides is actually pumpkin seeds (for mental clarity especially), and these are a good source of a few of the minerals you mention - magnesium, zinc and manganese. I've tried supplementing all these things individually, but with less results than I get from eating only 50g of seeds per day. I actually stopped eating these for some time as they are supposed to be a 5AR inhibitor, but reading into this in more detail it appears they do reduce DHT, but via a different mechanism to 5AR inhibition.  Have recently come off TUDCA after taking 600mg daily for 5-6 weeks (along with active B6, B12, folic acid, D3, selenium) as I was starting to feel a bit sh1t on it, and was getting pains in my liver (under right rib) just like I did when I'd come off tane. Having stopped it I feel fine again - probably a bit better than before even with better mental clarity. I'm not sure if I was becoming depleted in something on that regime, but will restart in a few weeks and add taurine and glycine!
  5. I took 10mg per day for 1 months and am still suffering from the sides over 5 years later. I think with regards to the epigenetic changes the amount may almost be irrelevant - one pill could 'flick the switch' as such, then you've got persistent side effects. There is at least one person on this thread who has persistent sides from a single pill.
  6. What has the bulletproof coffee helped with, I'm assuming improved mental clarity and concentration? Are the effects only for a period after drinking it, or has this resulted in any sort of progressive improvement in any way?
  7. Good to hear you're still having a positive effect from it. I'm guessing that will be down to it increasing BDNF. I've got some Noopept to try at some point, so it'll be interesting to see if that has an effect. I'm going to start twice weekly jogs to see if that lessens brain fog at all. I don't expect fast results though.
  8. Are you still taking tianeptine macleod, or have you phased this out? I'm currently taking the sups suggested by Mario Vitali with regards to his theory on reducing Endoplasmic Reticulum stress, however in the meantime I've been reading up on BDNF (Brain-derived neurotrophic factor) - low levels of which are associated with poor cognitive function/brain fog/derealisation which many people suffer from post tane (me included). Another member suggested that low BDNF could be a factor behind brain fog, and thing I've found that DEFINITELY result in an improvement for me are; - pine pollen - pumpkin seeds Pumpkin seeds are a very good source of zinc, and zinc has been shown as an effective way to increase BDNF. I've tended to snack on these regularly for quite a while now, but recently I was abroad on business and I noticed after a couple of days I felt quite brain fogged and quite introverted too, less chatty etc. I realised one thing I was missing from my diet was pumpkin seeds so I went out and managed to find a health food shop which sold pumpkin seeds, and within hours of eating some there was an improvement which I do not believe to be a placebo. Tianepetine is another thing that increases BDNF so I'm wondering if this could be factor in your improved mental sides. Noopept (another nootropic) also raises BDNF and Otto stated in a recent post that this pretty much completely cures his brain fog (but it appears only whilst taking it). Other ways to increase BDNF are.. no surprise, fasting (seems to be THE one single most beneficial thing for people trying to recover), good diet (low sugar, avoid processed foods) and exercise (intensive, e.g. running). Edit: Interestingly this study shows that zinc deficiency is also a factor in inducing Endoplasmic Reticulum stress; http://www.ncbi.nlm.nih.gov/pubmed/23748779
  9. What exactly did the Neurofeedback involve, I'm assuming a course of medication, if so what? Interesting about the DHEA. One thing that definitely helps lesson my brain fog (and also lessons effects of ED/loss of libido slightly) is pine pollen which contains a number of bio-available androgens - one of them being DHEA. I've generally been taking about a tea spoon of the pollen per day. Taking 3-4 for a few weeks really helped things, but then I started getting symptoms of excess estrogen like sensitive nipples. I may consider upping the dose whilst taking a natural aromatse inhibitor, but haven't done so yet.
  10. Yeah amino acids are actually the building blocks of proteins. As I understand it the theory goes that seeing as Accutane lowers HSP-70 (confirmed by the study below), this results in Endoplasmic Reticulum stress (the ER deals with unfolded proteins [but not as effectively when stressed]) and as a result you get an Unfolded Protein Response, so unfolded proteins which shouldn't be there, and are there in place of folded proteins that are required by the body for numerous processes. I'm not a biochemist, but it looks like a feasible theory, and seems to be backed up by a number of studies which appear to go some way to backing up the theory. Reduction of heat-shock protein-70 after prolonged treatment with retinoids: biological and clinical implications Regards glycine, I guess this could be a factor as its an amino acid which used to build the proteins, so if it's deficient as a result of raised GNMT enzyme activity in the liver using it up then maybe that further exacerbates the folding issue, or results in less proteins being produced? Either way it can't be good! Also potentially of interest is the fact that tane suffers who've had 23andme DNA tests done have seemed to have the marker for cystic fibrosis, and that condition is partially the response of unfolded proteins, so it may be just confirming the presence of excessive unfolded proteins (again just speculating).
  11. Continuing on from above, a key supplement in this guys recovery seems to be TUDCA which is a type of bile acid that can have rejuvenating effects on the liver, specifically normalising liver enzymes (a study Tryingtohelp2014 posted up recently showed highly elevated liver enzyme GNMT [Glycine N-methyltransferase] activity post tane), so there could well be something in this.. http://examine.com/supplements/tauroursodeoxycholic-acid
  12. Some guy is claiming he's recovered from his propecia side effects by taking supplements to prevent Protein Misfolding and Endoplasmic Reticulum (ER) Stress which he believes to be the root cause of the side effects caused by 5AR inhibitor drugs Accutane/Finasteride/Propecia, as well as CFS (Chronic Fatigue Syndrome). He does say he is still taking supplements, which in my book is generally not what I would consider a full recovery, but if he may well still be onto something, so it's not to be discounted. Worth checking out his post on the ATM forum, and also the thread he links to on phoenix rising. Lots of information to go through, I've just started to have a read through http://www.allthingsmale.com/community/threads/possible-treatment-for-finasteride-accutane-victims.25667