Almost 40 y.o.; have had acne to one degree or another since 4th grade! My skin is CLEAR. Not a single blemish. Normally get terrible cysts leading up to my period. This time, not a single one. I can't believe that this is what works, after years and years of trying so many things! I apply it every night. Wash with Cetaphil, very gently, no rubbing. Let my face air dry for about 20 min. Generously apply the cream, wait about 20 more min, then gently apply moisturizer.