hi WishClean, I've recently tried to start talking DIM for my pcos acne (source naturals brand) however, I can only take 1/3 of a pill without getting a massive headache and terrible detox acne.. even in conjuction with 1 Thorne Sat, in fact, I believe the liver supplement causes detox acne as well. I've only been able to take the dim and thorne sat for two days before giving up because the cystic acne I get afterwards is so so bad... I developed sore breasts, and a late period as well. I usually only get whiteheads, etc. is this normal? did you have a similar initial breakout to dim, and if so, how long does it last before seeing results? I got my hormones tested with a saliva panel, and I definitely have excess estrogen dominance and very low progesterone and normal but slightly high testosterone , so in theory, this supplement should help me. I should also mention that I am on 100mg of spironolactone, but it has lost 50% of its effectiveness, so I plan on weaning off of it slowly, as I'm very scared of more breakouts.. what would you recommend in this situation? also, thank you for this very informative post!