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  1. Did you show and talk to your neurologist about that test I mentioned?
  2. I think just because we haven't been able to reverse things, doesn't necessarily mean the problem didnt originate from the gut. Looking at Fecal transplants for example, look at what they screen their donors for. Donors are not allowed to have gastrointestinal diseases, autoimmune diseases, or the metabolic syndrome that might allow the patient to acquire a disorder caused by an interaction of the bacteria and the patient’s cells.Risks of developing autoimmune diseases may be reduced when your donor is a relative.
  3. To reput this, a bad gut can equal a bad liver. I think the neuron-gut connection is really good information to keep in mind. This doesn't necessarily have to be candida. (but if all you're taking is a straight up high dose antifungal drug, and you start to feel great, then you would know) From Medscape, 2015 Alcohol and Gut Microbiota The Possible Role of Gut Microbiota Modulation in the Treatment of Alcoholic Liver Disease gut flora plays an important role in the pathogenesis of alcoholic liver injury. gut microbiota modulation could be a target for the treatment of alcoholic liver disease. Talking about the safety of Prednisone, a short-term tapered, high dose course of prednisone should be safe (they probably look at risk factors like osteoporosis for example) A long term maintenance dose could be safe in the 5 to 10mg range.(not sure if this low dose would be effective) This is based on what I read, not experience. The point of all this though is if you have to go on some sort of treatment like this, especially if it had to be long term, Id want to know why and Id want to be able to pin it on the drug manufacturer if possible. Thats why id really push to get that test I mentioned if you can, so if it comes back positive, at least you have an idea of what might be going on, and go from there. Believe me I have had a TON of tests, and this one so far is the only indication of something abnormal. The headline would basically read, Nerve damage caused by Accutane. This isnt necessarily detected on standard nero tests, but it shows up as this antibody. I Just dont know about this until more people get tested. Autoimmune Autonomic Ganglionopathy (AAG) is a very rare form of dysautonomia in which the bodies own immune system damages a receptor in the autonomic ganglia (part of the peripheral autonomic nerve fiber). It is often associated with high titers of ganglionic acetylcholine receptor antibody (g-AChR antibody). AAG can impact people of all ages and both sexes. Approximately 100 Americans are diagnosed with AAG per year. AAG is a treatable antibody-mediated disorder of autonomic ganglionic synaptic transmission.
  4. No. I Have a neurologist appointment next week to discuss this test, I just got the result not too long ago. They treat this with plasma exchange, immune shots or prednisone depending on severity. This would justify him giving you prednisone. But the others might be more 1st line options. Im not sure how familiar he will be with this test, so you might need to really force the issue.
  5. Yea at least now you know, which helps people here out as well that have been wondering about this. I get the same head pressure your talking about. Alot of us do. Id seriously look into getting this test next time you go. You've probably seen me talk about it. Print this out, take it to your neurologist next time you go. Make sure your insurance will cover the cpt codes, its diagnostic, they should. I tested positive for this antibody GANG AChR Ganglionic Neuronal Ab, S highlight it for him. Tell him multiple people that took accutane are testing positive for this antibody and you want this test. We get one more person testing positive on this and it could really set things off. This could be related to some of your symptoms, this is something that could worsen with time. The sooner you know this, the better. This affects the nervous system, its autoimmune. Check out the video for more information if you want. This is something that could affect the brainstem or hypothalamus
  6. one of the last vitamins im looking at is k2 or mk7 or even mk4, I still have some concerns about the safety of mk7 (in how it interacts with everything) and even the bacteria its fermented with such as bacillus subtilis. I believe bacillus subtilis has been found in the human gi tract. Bacillus subtilis produces mk7. Bacillus subtilis is normally extremely resistant to antibiotics. Not only that, but looking at what might be possible as I mentioned what seems like a association with P. acnes bacteria. Kill the acne, kill the menaquinone or even suppress their production. InformationMenaquinone-specific isochorismate synthase Identifier: PPA1940Organism: Propionibacterium acnes KPA171202 Menaquinones are in the same gene neighborhood of P. Acnes. Your Current Organism: Propionibacterium acnes KPA171202 NCBI taxonomy Id: 267747 Other names: P. acnes KPA171202, Propionibacterium acnes DSM 16379, Propionibacterium acnes KPA171202, Propionibacterium acnes str. KPA171202, Propionibacterium acnes strain KPA171202 Predicted Interactions gene neighborhood gene fusions gene co-occurrence Im probably going to get this blood test to try to look into this The Genova Diagnostics Vitamin K Assay (Direct vs. functional measurement of vitamin K) The Genova Diagnostics Vitamin K Assay measures a functional marker, undercarboxylated osteocalcin (ucOC). Very little vitamin K is stored in the body therefore direct measurement is not ideal. @mariovitali Do you still believe strongly in vitamin k2 at this point? This test even has a cpt code for insurance, even without, its not that expensive. If you wanted to try to prove a possible association with k1/k2 and some of these syndromes, This would be a test to get.
  7. Anyways back to trying to be productive, i'm really not ^this guy.@tanedoutJorcruz said he had a lumbar puncture I thought this past week?@Jorcruz24You have that lumbar puncture? Well im not going to walk into the nearest ER and get a spinal tap like im buying a carton of milk, but if it comes to knowing this might be significant and reveal something I have no problem getting this done. (there are risks) Have you been seeing these posts? Tested positive for achr ganglionic neuronal antibody. So did someone else who took accutane. Odds 1 out of 15,000 people. This is a hell of alot easier then getting a spinal tap. This is autoimmune neurological involvement Its not that hard to imagine that after taking Accutane for a period of time the body started to reject what it was doing. It might have flipped a switch that stayed flipped.
  8. I think you got me all wrong. I dont care at all about being right. I care about getting it right. Why are you still here after so many years? I kind of get the feeling you're just hanging out. This isnt coffee hour for me, most people dont come here to chat. Im trying to move the chains. I think you might not be in a good place to help people. There is no delusion next time you spout off I know you're not really paying attention or even care and I'll completely ignore you. I think you're just looking for attention. I just think you're kind of fake on here. Mr. I got your back. If I could block your posts I would because I think you're more of a distraction than anything. Stop playing post police, let the posts be free. They wont hurt you, but I think you're capable of discouraging people on here by being a diva. Glad I spent time on this once again. Last time.
  9. Let me rephrase this. Respect gets respect. To me that last rant sounded like you were giving everyone the middle finger. If that was just directed at me, I dont care. So to recap, Im posting too much and its bothering you, you dont like what some other people are posting, and you want more people to pay attention to what your posting. You manage to be so oblivious to my postings, you confuse me with another user, not only that your not even aware some of what ive been most concerned about directly relates to what you just posted. For example you said you smoked some weed and had a stroke. Thats fucked up. Ive been talking about phospholipid antibodies they are saying could be drug induced that could lead to antiphospholipid syndrome or "thick blood" where people could be more prone to blood clots or risk of stroke.(I have them) Ive also talked about thrombosis risk based on genes like MTHFR. Ive also talked about calcification and trying to look into that by getting a carotid artery screening. and all you say is you're posting too much. Progress doesnt get made or things figured out by everyone posting less. Ive also talked about gingivitis that can progress to periodontal disease. This is Bacteria, Autoimmune and dry mouth. If your not paying close enough attention,(and that goes for everyone's postings) or logging on alot thats fine, You cant make these blanket statements though that discredit some things if you havent been following everything. When you stop and criticize people thats worse than the actual posts you're criticizing. Like what we're doing right now, I dont want to do this with you. Things will work themselves out. End Rant. Im sure your gonna say your peace and then we can move on. This is really all such a waste of time.
  10. I don't think it's candida. I'm just talking about respecting people.
  11. Looking at this study it looks like it shows increased cortisol levels due to hyperactivity of glands induced by retinoids. If this can be measured by just simple cortisol blood levels, then this is not the case post accutane. If this requires a stressor and then test cortisol blood levels then thats something to look into. This falls into whats been talked about recently. The difference is it was retinoid induced. It could have the same mechanisms and could still be autoimmune-like in nature if chronic. Treatment CFS FM.pdf Diagnosis and Treatment of Hypothalamic-Pituitary-Adrenal (HPA) Axis Dysfunction in Patients with Chronic Fatigue Syndrome (CFS) and Fibromyalgia (FM) This is a marker (antibody) that this^ might be going on. Achr ganglionic neuronal antibody. I tested positive for this antibody and so did babis. to put it in perspective 1 in 15000 test positive for this per mayo clinic. This is blood proof of autoimmune autonomic nervous system dysfunction. There is also real evidence of accutane being an environmental trigger to numerous autoimmune diseases (i've found a study or two myself along the way) The hypothalamus is responsible for the regulation of certain metabolic processes and other activities of the autonomic nervous system. It synthesizes and secretes certain neurohormones, called releasing hormones or hypothalamic hormones, and these in turn stimulate or inhibit the secretion of pituitary hormones. All we can do is look into all this until we can prove or disprove What might be going on. I've spent quite a few G's myself this year trying to figure it out. You had a guy that just had a lumbar puncture trying to figure it out, someone had to cross state lines just to get blood tests. You had a guy that said he was scared to post, but wanted to post because he thought it was Canidia and wanted to try to help people and took the time to do so. So please think about this shit before you go on your next rant.
  12. So I have to go back to this. What are you talking about here? I have a feeling you're just filtering over my posts because for some reason its making your blood boil a little bit. If something I said offended you, my best advice would be to let it go. I think your looking at things the wrong way. Im not trying to dominate this thread. Everyday im just trying to push things or move the needle just a little bit more. Some people might be in a better position to look into some of these things, whether that's finances, insurance, geographical location or just plain relentlessness. I dont view this as a criticism but an advantage.
  13. saw you scratched this. Here is the study. They're saying it was more potent than antibiotics. The effects of systemic isotretinoin and antibiotic therapy on the microbial floras in patients with acne vulgaris systemic isotretinoin and antibiotic treatments in acne patients precisely caused variations in the microbial floras of several sites of the body, while isotretinoin was commonly more responsible than antibiotics. My main concern isnt trying to repopulate the gut with probiotics or fight some candida or bacterial infection, its if this could have had a long term deleterious effect on menaquinones. They are biologically similar to P. Acnes bacteria.
  14. @macleod What time is it over there? Can I join you for a beer? This is some misdirected hostility and you insult and disrespect alot of people on this thread. This is where it gets derailed. Why should people respect what you are saying? No One's ever gotten anywhere on this forum because, people need to check their egos at the door. Also some of the things you are saying are being passed as fact when they are assumptions. Antibodies can mediate some of what you mentioned. I have a few of them to prove it.
  15. Was this a standard blood test? A bunch of people were supplementing this awhile back. Some started to say they felt worse. So might be best to leave it alone. Or supplement cautiously. Probably not a big factor idk. Have you had this test? I havent looked into this too extensively myself. These blood levels could be related to autonomic nervous system dysfunction. This still might still be worth looking into, its not top on my list atm though. Peripheral and central effects of circulating catecholamines. While these rapid responses may be necessary for survival, sustained elevation of circulating catecholamines for prolonged periods of time can also produce pathological conditions, such as cardiac hypertrophy and heart failure, hypertension, and posttraumatic stress disorder. In this review, we discuss the present knowledge of the effects of circulating catecholamines on peripheral organs and tissues, as well as on memory in the brain.
  16. So this is concerning, especially if allowed to go on for a period of time not knowing. Vitamin K Deficiency Linked to Osteoporosis, Cancer, and Heart Disease Operating under the “triage” theory for micronutrients—a theory that suggests the body prioritizes the use of scarce micronutrients like vitamin K in favor of short-term survival at the expense of long-term health—the researchers looked at the consequences of vitamin K restriction amongst vitamin K-dependent proteins. What they found was truly frightening. When the supply of vitamin K was limited, as it is in the typical American diet, the body utilizes it to protect critical metabolic functions in the liver. Unfortunately, that leaves other vitamin K-dependent proteins, the ones associated with bone building, cancer prevention, and protecting the heart from atherosclerosis, without sufficient vitamin K to function properly. The result of this deficiency leaves the body at risk for developing age-related disease like cancer, heart disease, and osteoporosis. I found a test to maybe catch this. Even a simple k1 blood test might as well. The Genova Diagnostics Vitamin K Assay (Direct vs. functional measurement of vitamin K) The Genova Diagnostics Vitamin K Assay measures a functional marker, undercarboxylated osteocalcin (ucOC). Symptoms & conditions related to vitamin K deficiency Bruising Epistaxis Fractures Gastrointestinal bleeding Menorrhagia Hematuria Nosebleeds Anemia Osteopenia/Osteoporosis Calcification of soft tissue, especially heart valves Digestive problems, especially malabsorption Cardiovascular Disease Cancer Malabsorption syndromes So of course in the back of my mind ive had thoughts that maybe Babis is dead as fuck, and Im about to be dead as fuck, and Ive been giving you guys the play by play on finding out I have cancer. Hopefully thats not the case, because that would sure be a bummer. Ive had alot of scans and tests though recently and they've been clear, so I dont know where it would be hiding. I wonder what kind of number Babis tested on that achr antibody, I wonder if he had any screenings. Had to post this just in case. @ACCUiTy_drANE What was that post you posted about someone developing cancer (brain?) post tane. Did they find that to be related? any studies on this? I mean Accutane is used to treat cancer.
  17. Something isnt right with zinc. I wouldnt supplement it. I know ive talked about it positively recently, but like just mentioned this might be feeding or strengthening some pathogen. The body is not handling it correctly or over reacting to it. The thing about supplements is your just as likely to find something that's harmful.
  18. Theres antibody testing for this. It looks to be up to 70 to 80 percent accurate. Even walkin lab tests all the antibodies for 199. This could be a worthwhile test. if you can find it, I thought someone did say on here they tested positive for candida antibodies. Dont remember the details. Ehohel said he felt 100 percent on prednisone. If there was a candida infection that was causing systemic effects ( obviously it's not in the blood, would have to be coming from the gi tract) he should have felt worse theoretically on prednisone. Alot of people have had endoscopies and have shown no signs of Candida( maybe its possible to miss) if its in the lower bowels people have also had colonoscopies. if this was going on out of control you would think some people would develop thrush. What eph95 was taking might have been beneficial in helping reset the gut, regardless of a Candida infection or not. Not discrediting this though. Keep us updated and give it more time. Detection of Candida albicans antigen in serum is highly suggestive of systemic or disseminated candidiasis. Systemic candidiasis is often characterized by markedly elevated levels of IgG, IgA, and IgM recognizing Candida. However, interpretation of Candida antibody levels is complicated by detection of antibodies in 20-30% of healthy individuals, and blunted antibody responses in immuno-compromised patients at risk for systemic candidiasis. Candida antibody results should be considered within the context of clinical findings and results from other relevant laboratory tests, such as Candida antigen detection and/or culture. Actually looking at this again real quick, this testing might be for more life threatening type Candida. Which obviously isnt the case. Testing for Gut Candida? Fecal test? This would also maybe show up on stomach biopsy though, which people have had, or show white patches. Idk really atm.
  19. Have you been taking anything that could be hard on the liver? Elevated liver enzymes may be discovered during routine blood testing. In most cases, liver enzyme levels are only mildly and temporarily elevated. Most of the time, elevated liver enzymes don't signal a chronic, serious liver problem. Thinking of fibroscan and fibrosis. I would think this doesnt happen overnight. If you're curious you could always look into getting a fibroscan. Based on your location there might be some testing nearby. Find a FibroScan - Echosens Just something else to rule out. (or in) with the majority of us not showing signs of liver injury, the only thing left to check would be a fibroscan. But you rule this out in a few people, then you narrow this process down even more. The most logical thing would be to retest your liver enzymes after a period of time.
  20. Looking at associations with P.Acnes and Menaquinones real quick. The transcriptome analysis revealed how HPTs can impact the expression of genes, and thereby potentially affect phenotypes, primarily between clades. Although P. acnes is a highly clonal species, small changes and even SNPs may have an impact on the phenotype. In the absence of effective means of adapting to new challenges, HPTs may serve as a simple method for inactivation of genes or even adjustment of expression levels. example is HPT_37, which is located upstream of PPA1943, encoding a putative ubiquinone/menaquinone biosynthesis C-methylase (UbiE) that is required for biosynthesis of ubiquinone (coenzyme Q) or menaquinone (vitamin K2). Propionibacteria - Page 41 - Google Books Result Leha Vorobjeva - 2013 - ‎Medical (1994) emphasized such properties of P innocuum as the aerobic growth potential and ... and Propionibacterium are also similar in relation to menaquinones. ... Act viscosus, P. freudenreichii and P.acnes confirmed that A. propionica is more ... Propionibacterium acnes - Wikipedia
  21. Also still waiting on my carotid ultrasound results to see if any premature calcification might be going on that might agree with a k2 deficiency. And it sure as hell better not agree too much. just found this. Menaquinone Analogs Inhibit Growth of Bacterial Pathogens › NCBI › Literature › PubMed Central (PMC) by PM Schlievert - ‎2013 - ‎Cited by 10 - ‎Related articles Effects of menaquinone and analogs on growth are presented as means .... Production of the cell surface protein protein A was increased at coenzyme Q1 ... Im about done with supplements. One of the last ones im still wondering about is k2 or mk7. k2 is still sort of mysterious in all the processes its involved in. There is no direct testing for this. it possibly interplays with bacteria. These functions stand out to me for k2 Coagulation factors (II, VII, IX, X), as well as anticoagulation proteins (C, S, Z). These Gla-proteins are synthesized in the liver and play an important role in blood homeo-stasis. Osteocalcin. This non-collagenous protein is secreted by osteoblasts and plays an essential role in the formation of mineral in bone. Matrix gla protein (MGP). This calcification inhibitory protein is found in numerous body tissues, but its role is most pronounced in cartilage and in arterial vessel walls. Growth arrest-specific protein 6 (GAS6). GAS6 is secreted by leucocytes and endothelial cells in response to injury and helps in cell survival, proliferation, migration, and adhesion. Proline-rich Gla-proteins (PRGP), transmembrane Gla-proteins (TMG), Gla-rich protein (GRP) and periostin; whose precise functions are still unexplored. I think depending on when you took accutane, it sort of freezes your body in time or stops growth. People have remarked how they still look the same or young after many years. Obviously this process might not be natural and might start to present with problems down the line. Growth Arrest.
  22. This is looking at menaquinones or lack of possibly affecting gut microbiology or vice versa. from 2015. Changes in Fecal Vitamin K Content are Associated with the Gut Microbiota Though gut bacteria synthesize MK-n, relationships between gut microbiota composition, MK-n biosynthesis, and cardiometabolic health have not been examined. Findings suggest that variability in fecal MKn content is associated with the gut microbiota, and that diet-mediated changes in gut microbiota composition may alter gut MK-n content. The implications for human health merit further investigation
  23. Menaquinones oxidize and reduce copper. Initially this sounds like increased toxicity, but this might be a good thing and makes the body less sensitive to copper. I might have the blood test to prove it. This could be where high estrogen and low testosterone is coming from. Menaquinone might have some interplay with zinc and iron as well. Menaquinones might almost be a bacteria in itself.
  24. I think it depends on the Dr or place. There are some Gastro doctors that look at and recognize sibo, fibromyalgia, chronic fatigue with gut microbiota and the possible connections.
  25. This is what I've also mentioned. what happened because of Accutane treatment might not be specific to accutane. I posted a study awhile back showing accutane can basically act like a super antibiotic. This could then fall in line with some cfs/me theories. It could have caused some gut imbalance that triggered autoimmunity. Mario thinks it's the liver, I'm kind of leaning towards the gut.