starrfeesh

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About starrfeesh

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  1. Thinking of adding SAMe to this protocol as well. Has anybody had any luck with SAMe? This study shows it's effective in treating cholestasis. https://www.ncbi.nlm.nih.gov/pubmed/2081476
  2. I bought mine at irc.bio (no script needed) Also a couple of months back, Joseph Buchignani mentioned an online Dr. that would write scripts for it as well.
  3. Did anybody try/stick with the protocol from the youtube video '8 tips reversing accutane side effects?' I know quite a few of us were taking calcium d glucarate for a while, some with good results, but curious if anybody tried all the recommendations? The video mentions pale stools are a sign of cholestasis, which I do have. I think I'm going to give that protocol a try a long with LDN. Will let you all know how I get on.
  4. Im 10 years post-tane and I've done everything possible to address gut health and nothing has worked better than LDN. Digestion isn't perfect but its good enough that I don't think about it constantly anymore. I think our retinoic acid (vitamin a) receptors are, for lack of a better term, shot. The same way the body will build a tolerance to anything that its receiving too much of. I think our retinoic acid receptors would down regulated or fried from the constant burden of having to deal with all the synthetic vitamin a being thrown at them. There are people who know a lot more about this than me, but I think we need a retinoic acid antagonist. The same mechanism that LDN works for natural opioid receptors, may be effective for our vit a recptors. Naltrexone at very low doses blocks your opioid receptors and the body responds by upregulating those receptors, making your more sensitive/receptive to the natural opioid. Personally, I believe we're chronically deficient in vit a. My symptoms definitely align with this anyways. I know that too much vit a sypmtoms are similar but I've avoided it and never improved just slowly have gotten worse. I think we cant handle vit a not because we're already overloaded with it, but because our body cant properly receive it. I have no idea if this is even plausible but if we could use a retinoic acid inhibitor at a very low dose to to temporarily occupy the (few) receptors we do have, and trigger the body to naturally upregulate these receptors we may be able to process vitamin a again. Its completely possible that accutane has fried other receptors as well, I have no idea. I do know that LDN has worked better and more consistently/long term than anything else i"ve tried, and I've tried everything. This is my current thought anyways. I know there are a lot of people in this forum much more educated on the subject than me, and would love to hear their thoughts or if this route has already been tested. I think we are trying to address “down river” symptoms. If we don’t address the problem at the top than we just continue to manage symptoms with no resolve. It’s completely possible our receptors are fried beyond repair and our only choice is to manage the symptoms. But I haven’t heard of anyone trying this yet, may be worth looking into. I have seen in studies they claim they don’t think isotretinoin affect RAR RXR receptors but I have my doubts. I do know that LDN helps a ton of people with a broad range of issues and the mechanism is unique. Hopefully using the same mechanism but targeting different receptors could work. Somebody mentioned Dr. Pezzi’s method, which I believe is similar to what I’m getting at, and apparently he had great results addressing sexual dysfunction.
  5. Accutane reduces the levels of testosterone receptors in your body. The article below applies this to the skin - which must account for a lot of testosterone reception as the skin is a large area of the human body - but what's to say that this doesn't occur for all testosterone receptors in the body? You will test normal on testosterone level and DHT after taking Accutane. However, the message is going around, but no-one is there to receive it: the receptors for the testosterone in your body are decreased 2.6 fold by Accutane, as proved below. And this is just after 3 months. Rather than the removal of your balls from the outside of your body, your ability to receive the testosterone is removed from the inside of your body. Effect of oral isotretinoin treatment on skin androgen receptor levels in male acneic patients P Boudou, H Soliman, M Chivot, JM Villette, P Vexiau, A Belanger and J Fiet Department of Hormonal Biology, St. Louis University Hospital, Paris, France. 'Androgen receptor status was investigated in back skin biopsies obtained in acne areas before and after 3 months of isotretinoin treatment. The treatment did not modify the binding affinity constant of skin androgen receptor (0.44 vs. 0.32 nmol/L), but it did induce a 2.6-fold decrease in its binding capacity constant (62 vs. 24 fmol/mg cytosolic protein), as assessed by Scatchard plot and confirmed immunologically by Western blot analysis. These data clearly showed that skin androgen receptor was sensitive to oral isotretinoin administration in acneic patients. The decrease in skin androgen receptor levels (this study) and the recently reported suppression of skin 5 alpha-dihydrotestosterone production by isotretinoin treatment appeared consistent with the involvement of androgen receptor and 5 alpha-dihydrotestosterone in the pathogenesis of acne. Indeed, sebum production is under androgen control, and an abnormal response of the pilosebaceous unit to androgens appears to be implicated in the pathogenesis of acne. These observations were consistent with the absence of sebum in complete androgen-insensitive patients and normal sebum production in male pseudohermaphrodites.' This was posted by the user: Violence back in 2008. But this supports the the idea that we may need to upregulate receptors. As mentioned in previous posts, one way that may work is by temporarily blocking the receptors so that the body naturally produces more, the same way LDN works. Dr. Pezzi's approach makes sense to me but the idea of taking another pharmaceutical thats shown to harm people scares me.