I'm taking a teaspoon of the powder twice a day. Not sure how much that is in grams, I guess 5-10g. I too noticed improved mental clarity on MB12, didn't try AB12. I'm taking MB12, MFolate and P5P once or twice a week for insurance basically and because I still have some left, but I don't notice any profound effect anymore in contrast to TMG or Creatine. Dead giveaway for functioning methylation is my sense of smell being very sensitive, i.e. my sinuses being clear. Can't remember to ever have had such a good sense of smell. Also my hair doesn't get greasy anymore and my skin looks great. WIth methylation there seems to be indeed no one-size-fits-all approach so it is necessary to experiment. Yes, I've tried various dietary changes but haven't sticked to anything except gluten-free, whole food. I try to eat balanced meals and take Taurine occasionally which supports bile function, so I suspect my fat digestion is probably somewhat impaired, too. As for other supplements I also take Magnesium, Vit D, Vit K2 and Zinc occasionally which improve my energy levels. Doesn't work every time though, so I guess sometimes they are bottlenecks and sometimes something else is. Vit A doesn't affect me in any way. Also benefitted from going pornfree/nofap.
Hi guys, I posted in this thread a couple years ago, my symptoms were mostly about constipation, cognitive deficits and fatigue. Here's what works for me. The cognitive deficits and fatigue are 90% under control if I take enough methyl donors. So Trimethylglycine, Creatine, Methylfolate, MethylB12, P5P, NAC, all work to some degree. Personally I find Trimethylglycine second most effective, cheap, and easy to consume (tastes a little sweet). Creatine was most effective, but made my hair fall out, or at least that was my perception. Dosage for Trimethylglycine would be a teaspoon of the powder twice a day. More Information here: https://examine.com/supplements/trimethylglycine/ My digestion is unfortunately still troubling me. I got it working for some time and then at some point symptoms reappeared. Imho it's all about intestinal permeability, also called leaky gut. Glutenfree is necessary and helpful but not sufficient in my case. I haven't benefitted from pre- or probiotics.