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About JosephBuchignani

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  1. Repairing the long-term damage from Accutane

    @Nick Ryan I see similarities in your signature to my condition. And also in your engineer's mindset. FYI: White rice is fundamental to my diet. LDN was the lynchpin of my recovery. Carry on!
  2. Repairing the long-term damage from Accutane

    > I plan to cut the capsules in half, as 2.2 mg seems to be in the range many clinicians use for autism, inflammatory diseases, cancer, etc. IMHO this is a bad plan. 4.5mg is the standard. You may need slightly more or significantly less, but you should determine that experimentally. Don't cut the pills in half. It's stable in a water solution for a month. You have to dissolve it anyway. Just take more or less liquid according to desired dose. If you cut the pills it will be imprecise, introducing error into your dosages.
  3. Repairing the long-term damage from Accutane

    > Surely we've all now concluded that any test is a waste of time No. Fecal calprotectin test added years to my life, and hugely improved quality of life.
  4. Repairing the long-term damage from Accutane

    > It concludes that Naltrexone is not so risk free as I thought before, but at the other hand it can really help Considering how much difficulty sick people have merely grasping the concept of gradual dosage titration, much less correctly implementing it, plus the potential for side-effect misattribution, I'm skeptical of the gross side effect numbers. I have yet to see anyone say: "I halved the dose whenever there was trouble, but just couldn't manage to gradually build up to the normal dosage range over a few months. I ran into a side-effect wall every time."
  5. Repairing the long-term damage from Accutane

    I got around to resuming my LDN regimen and Googled it a bit to refresh my memory: 1. It lasts 30 days in the fridge. I'd thought the liquid shelf life was shorter. So I strongly recommend that only one person per country purchase and then share a few pills with all those who wish to trial it. 2. The slow dosage increase recommended in one report I saw was .5mg / week. So a 1-3 month ramp up. 3. Most obvious side effect for me of overly aggressive ramp-up is still sleep shortened by an hour or two, less satisfying sleep, and more vivid dreams. In a 4.5mg / 90 ml solution, I started at 1 ml, jumped to 3, then to 7, then to 5, might drop to 3. Just feeling it out. Other factors affect my sleep too. (Adding garlic certainly contributed to the sleep issue, and maybe solely accounts for it.) A full daily dose is 90ml or 4.5 mg. In general I tend to modify multiple variables at once and become more conservative or more aggressive in waves based on daily biofeedback. Since I had the aforementioned mild sleep impact I'll now eliminate variance except LDN to dial in the correct dosage increase schedule. I'm still doing great but I pay close attention to sleep quality as a KPI. My definition of "doing great" is e.g. being productive at software development without any particular biological strain. info pack - US - 2014.pdf