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About JosephBuchignani

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  1. Repairing the long-term damage from Accutane

    @Nick Ryan I see similarities in your signature to my condition. And also in your engineer's mindset. FYI: White rice is fundamental to my diet. LDN was the lynchpin of my recovery. Carry on!
  2. Repairing the long-term damage from Accutane

    > I plan to cut the capsules in half, as 2.2 mg seems to be in the range many clinicians use for autism, inflammatory diseases, cancer, etc. IMHO this is a bad plan. 4.5mg is the standard. You may need slightly more or significantly less, but you should determine that experimentally. Don't cut the pills in half. It's stable in a water solution for a month. You have to dissolve it anyway. Just take more or less liquid according to desired dose. If you cut the pills it will be imprecise, introducing error into your dosages.
  3. Repairing the long-term damage from Accutane

    > Surely we've all now concluded that any test is a waste of time No. Fecal calprotectin test added years to my life, and hugely improved quality of life.
  4. Repairing the long-term damage from Accutane

    > It concludes that Naltrexone is not so risk free as I thought before, but at the other hand it can really help Considering how much difficulty sick people have merely grasping the concept of gradual dosage titration, much less correctly implementing it, plus the potential for side-effect misattribution, I'm skeptical of the gross side effect numbers. I have yet to see anyone say: "I halved the dose whenever there was trouble, but just couldn't manage to gradually build up to the normal dosage range over a few months. I ran into a side-effect wall every time."
  5. Repairing the long-term damage from Accutane

    I got around to resuming my LDN regimen and Googled it a bit to refresh my memory: 1. It lasts 30 days in the fridge. I'd thought the liquid shelf life was shorter. So I strongly recommend that only one person per country purchase and then share a few pills with all those who wish to trial it. 2. The slow dosage increase recommended in one report I saw was .5mg / week. So a 1-3 month ramp up. 3. Most obvious side effect for me of overly aggressive ramp-up is still sleep shortened by an hour or two, less satisfying sleep, and more vivid dreams. In a 4.5mg / 90 ml solution, I started at 1 ml, jumped to 3, then to 7, then to 5, might drop to 3. Just feeling it out. Other factors affect my sleep too. (Adding garlic certainly contributed to the sleep issue, and maybe solely accounts for it.) A full daily dose is 90ml or 4.5 mg. In general I tend to modify multiple variables at once and become more conservative or more aggressive in waves based on daily biofeedback. Since I had the aforementioned mild sleep impact I'll now eliminate variance except LDN to dial in the correct dosage increase schedule. I'm still doing great but I pay close attention to sleep quality as a KPI. My definition of "doing great" is e.g. being productive at software development without any particular biological strain. info pack - US - 2014.pdf
  6. Repairing the long-term damage from Accutane

    Yes. Supps didn't work. Was more or less starving to death, very slowly.
  7. Repairing the long-term damage from Accutane

    No, you do not inject LDN. The graduated syringe is for measurement.
  8. Repairing the long-term damage from Accutane

    I was talking about LDN. I edited my post to reflect this. I wouldn't say LDN is a magic bullet for sleep. Changes to sleep are just its only noticeable effect. If you are failing to thrive and sleeping poorly as a result, then you must heal the underlying health issue before sleeping well. So you should observe CHANGES to sleep quality, but not expect a great night's sleep right away, like you would with a sleeping pill.
  9. Repairing the long-term damage from Accutane

    Answering an LDN question sent by PM for benefit of all: > Did you start your initial does at 1.5mg at night? and how long did you wait to titrate your dose up and how high of a dose did you settle on? 1.5mg is WAY TOO HIGH. You dissolve the 4.5mg pill in 90ml distilled water, and have a 10 ml syringe. There's no reason to be aggressive, especially if you have a history of hypersensitivity. Start at 1 ml. Double it daily until you notice a sleep impact. Then back up off if your sleep has shortened or fatigue has increased. Stay in the sweet spot of excellent sleep as the dose gradually increases. There's NO BLOODY HURRY. After 2-3 months you might be at 4.5mg / night. I think I eventually got there. No reason to go higher. If you start too high, you will screw up your sleep, which obviously makes everything worse. Just like improving your sleep makes everything better. To understand its effect on sleep, compare to Huperzine A. Can I guarantee it will work for you? No. Did it save me from a life not worth living? Yes.
  10. Hey Joseph,

    Thats great that your fine so much better, I was wondering did you have any drones issues, did that return for you as well.

    Also for the trial, what dos did you start off on?




  11. I am interested in LDN for my flushing as i am sure it is some sort of immune system problem brought on by accutane. What problems did LDN "cure" for you? How long did it take? Would LDN potentially help for something like flushing? Thanks for everything!

  12. Repairing the long-term damage from Accutane

    My understanding is that I'm the first in this community to use or think about using LDN. Updated my sig with some basic LDN instructions. I would recommend that those living in the same country pool resources, have one person get an LDN script, and then that person can mail a few pills to each member. You only need a very small amount to test whether it will work, since for most of the first month you are taking much smaller than normal doses. A prescription is typically for 6 months. A proper trial might last 5 weeks. You could do a mini 3 day trial just to see whether you get an initial "rested" bump. LDN destabilizes when dissolved into water for metered dosing, so a minimum quantity would be 1 pill per 3 days of trial period. I think my gut is still more reactive than when this began, but it's within normal familial ranges so that might just be aging and hard living. I could probably improve it further if I focused on it. Not caring much is the strongest sign that I'm cured, since I'm a very utilitarian person. If it were getting in my way, I'd still be obsessed.
  13. Repairing the long-term damage from Accutane

    Thanks for volunteering to mod, Chico. Sea of tangents is apt. Glad someone else sees the vision. I've got an unrelated major forum migration to do tonight, and plenty of work after that. My mod requirement is satisfied, so the accutane forum project has moved from "maybe" to "someday". If someone buys a Xenforo license, that will upgrade it to "< 1 week". Still cured thanks to LDN, btw. Someone mentioned night blindness; I had that at my worst due to low vitamin A.
  14. Repairing the long-term damage from Accutane

    > I think a forum would be a great idea. I'm just not sure whether our community is large enough to have fill it. If one was made though, I would contribute This community leaks like a sieve due to the terrible format, and despite that it's still overcrowded. The flamewar surrounding amar is just the latest example demonstrating that this format is crippled. There's no shortage of users. What's missing are mods, leaders, people willing to invest in the project's success. Primarily, this means keeping up with the moderation queue and putting out small fires. This prevents "broken window" syndrome, wherein a small amount of entropy encourages everyone to disrespect the platform further. It's pointless to start a forum without a dedicated mod team, because you'd just have to immediately lock it. Otherwise an entropy debt would build that would discourage any future moderator from accepting the role. If you don't have any leaders, then you're going to keep flaming amars forever.
  15. Repairing the long-term damage from Accutane

    Apparently there's no interest in creating a forum. I'll check back once or twice more, maybe, and I've thrown it onto my "someday/maybe" to do list.
  16. Repairing the long-term damage from Accutane

    > Good luck with recovering. I am recovered. My body functions as it did before, more or less. I went from being able to eat nearly nothing to being able to eat most things. 130 lbs to 167 lbs at 6'. Dead to alive. Everything else I tried at best let me maintain a little longer, hold back the decline another month or year. Only LDN mattered. ---- What you guys should do is buy a Xenforo license, then build a forum that is a combination of personal communities / support groups in one section and organized, disciplined topical information in the other. This would give you a spam-resistant long-term platform. Your efforts are crippled in this format, as you've repeatedly observed. If someone else will buy the license, I will do the hosting, installation, configuration, and training for the admin/mod team. But it would greatly help my enthusiasm for the project if someone tried LDN properly and reported back. There is no possibility of a scam here. The license remains in the hands of the buyer and can't even be transferred for 6 months. I already do this for a different (private) project, in exactly the same way. Just get the basic license. No addons needed. Post here first if you're going to buy it so two people don't buy it. I really do hate Roche, I really do pity the horrible ongoing suffering. I really did almost lose everything to this. I really do want to stop another person from taking Accutane. But I had to think long and hard about making this offer. I'm busy with things that matter even more to me. I'm not sure whether I can count on followthrough from this debilitated, demoralized community. At first, I wrote this post as advice, not an offer. But then I realized that it would take a large amount of time and effort for someone to duplicate what I can do easily and quickly. I think there are serious, organized, dedicated, intelligent people here. And there are also bleeding souls who need a place to vent, without it getting in the way of business. Channeled properly, we might even fell the giant that laid us low. They owe me 10 years of shame. I want that back, with interest. The aforementioned serious, organized, dedicated, intelligent people are the ones I'd count on to be moderators, because it's not something I have the bandwidth for. Talk is cheap, but the Xenforo license is $140. I'd be nuts to invest the kind of work I'm talking about if there wasn't sufficient community interest to cover that. No, I won't accept partial donations. Let someone else here you know and trust do that, if none of you can cover the whole price. Otherwise, if you want to go the nearly free DIY route, use phpBB with Namesilo will give you a cheap non .com domain. However, I won't be involved. One thread, 417 pages. Wow.