JosephBuchignani

Veteran Member
  • Content count

    381
  • Joined

  • Last visited


Community Reputation

91 Excellent

6 Followers

About JosephBuchignani

Veteran Member

Achievements

Bronze Poster
Posted at least 100 different posts
20 posts
100 posts
500 posts
2000 posts
No reviews awards
Review at least 1 product
1 product
5 products
10 products
25 products

Recent Profile Visitors

3,745 profile views
  1. Repairing the long-term damage from Accutane

    @Nick Ryan I see similarities in your signature to my condition. And also in your engineer's mindset. FYI: White rice is fundamental to my diet. LDN was the lynchpin of my recovery. Carry on!
  2. Repairing the long-term damage from Accutane

    > I plan to cut the capsules in half, as 2.2 mg seems to be in the range many clinicians use for autism, inflammatory diseases, cancer, etc. IMHO this is a bad plan. 4.5mg is the standard. You may need slightly more or significantly less, but you should determine that experimentally. Don't cut the pills in half. It's stable in a water solution for a month. You have to dissolve it anyway. Just take more or less liquid according to desired dose. If you cut the pills it will be imprecise, introducing error into your dosages.
  3. Repairing the long-term damage from Accutane

    > Surely we've all now concluded that any test is a waste of time No. Fecal calprotectin test added years to my life, and hugely improved quality of life.
  4. Repairing the long-term damage from Accutane

    > It concludes that Naltrexone is not so risk free as I thought before, but at the other hand it can really help Considering how much difficulty sick people have merely grasping the concept of gradual dosage titration, much less correctly implementing it, plus the potential for side-effect misattribution, I'm skeptical of the gross side effect numbers. I have yet to see anyone say: "I halved the dose whenever there was trouble, but just couldn't manage to gradually build up to the normal dosage range over a few months. I ran into a side-effect wall every time."
  5. Repairing the long-term damage from Accutane

    I got around to resuming my LDN regimen and Googled it a bit to refresh my memory: 1. It lasts 30 days in the fridge. I'd thought the liquid shelf life was shorter. So I strongly recommend that only one person per country purchase and then share a few pills with all those who wish to trial it. 2. The slow dosage increase recommended in one report I saw was .5mg / week. So a 1-3 month ramp up. 3. Most obvious side effect for me of overly aggressive ramp-up is still sleep shortened by an hour or two, less satisfying sleep, and more vivid dreams. In a 4.5mg / 90 ml solution, I started at 1 ml, jumped to 3, then to 7, then to 5, might drop to 3. Just feeling it out. Other factors affect my sleep too. (Adding garlic certainly contributed to the sleep issue, and maybe solely accounts for it.) A full daily dose is 90ml or 4.5 mg. In general I tend to modify multiple variables at once and become more conservative or more aggressive in waves based on daily biofeedback. Since I had the aforementioned mild sleep impact I'll now eliminate variance except LDN to dial in the correct dosage increase schedule. I'm still doing great but I pay close attention to sleep quality as a KPI. My definition of "doing great" is e.g. being productive at software development without any particular biological strain. http://www.ldnresearchtrust.org/sites/default/files/Doctors info pack - US - 2014.pdf
  6. Repairing the long-term damage from Accutane

    Yes. Supps didn't work. Was more or less starving to death, very slowly.
  7. Repairing the long-term damage from Accutane

    No, you do not inject LDN. The graduated syringe is for measurement.
  8. Repairing the long-term damage from Accutane

    I was talking about LDN. I edited my post to reflect this. I wouldn't say LDN is a magic bullet for sleep. Changes to sleep are just its only noticeable effect. If you are failing to thrive and sleeping poorly as a result, then you must heal the underlying health issue before sleeping well. So you should observe CHANGES to sleep quality, but not expect a great night's sleep right away, like you would with a sleeping pill.
  9. Repairing the long-term damage from Accutane

    Answering an LDN question sent by PM for benefit of all: > Did you start your initial does at 1.5mg at night? and how long did you wait to titrate your dose up and how high of a dose did you settle on? 1.5mg is WAY TOO HIGH. You dissolve the 4.5mg pill in 90ml distilled water, and have a 10 ml syringe. There's no reason to be aggressive, especially if you have a history of hypersensitivity. Start at 1 ml. Double it daily until you notice a sleep impact. Then back up off if your sleep has shortened or fatigue has increased. Stay in the sweet spot of excellent sleep as the dose gradually increases. There's NO BLOODY HURRY. After 2-3 months you might be at 4.5mg / night. I think I eventually got there. No reason to go higher. If you start too high, you will screw up your sleep, which obviously makes everything worse. Just like improving your sleep makes everything better. To understand its effect on sleep, compare to Huperzine A. Can I guarantee it will work for you? No. Did it save me from a life not worth living? Yes.
  10. Hey Joseph,

    Thats great that your fine so much better, I was wondering did you have any drones issues, did that return for you as well.

    Also for the trial, what dos did you start off on?

    Thanks, 

    Khristina




















     

  11. I am interested in LDN for my flushing as i am sure it is some sort of immune system problem brought on by accutane. What problems did LDN "cure" for you? How long did it take? Would LDN potentially help for something like flushing? Thanks for everything!

  12. Repairing the long-term damage from Accutane

    My understanding is that I'm the first in this community to use or think about using LDN. Updated my sig with some basic LDN instructions. I would recommend that those living in the same country pool resources, have one person get an LDN script, and then that person can mail a few pills to each member. You only need a very small amount to test whether it will work, since for most of the first month you are taking much smaller than normal doses. A prescription is typically for 6 months. A proper trial might last 5 weeks. You could do a mini 3 day trial just to see whether you get an initial "rested" bump. LDN destabilizes when dissolved into water for metered dosing, so a minimum quantity would be 1 pill per 3 days of trial period. I think my gut is still more reactive than when this began, but it's within normal familial ranges so that might just be aging and hard living. I could probably improve it further if I focused on it. Not caring much is the strongest sign that I'm cured, since I'm a very utilitarian person. If it were getting in my way, I'd still be obsessed.
  13. Repairing the long-term damage from Accutane

    Thanks for volunteering to mod, Chico. Sea of tangents is apt. Glad someone else sees the vision. I've got an unrelated major forum migration to do tonight, and plenty of work after that. My mod requirement is satisfied, so the accutane forum project has moved from "maybe" to "someday". If someone buys a Xenforo license, that will upgrade it to "< 1 week". Still cured thanks to LDN, btw. Someone mentioned night blindness; I had that at my worst due to low vitamin A.