Most of my side effects (ie digestive problems, low energy, depression) have disappeared since starting low-dose Naltrexone therapy. I finally found a doctor who would prescribe me Naltrexone (for alcohol use technically) and let me make my own doseage by disolving the pills in distilled water. I cant tell you guys how wonderful it is to feel generally "normal" again after so many tears of suffering after Accutane. For those who dont know about LDN, it is an opiate blocker that at low doses tricks tbe body into producing more endorphins, thereby normallizing and boosting the immune system. Our immune systems must be damaged by Accutane, evidenced by the many cases of autoimmune diseases that show up post-'tane such as Colitis, crohns, food allergies, fibromyalgia, etc.