Isottetinoin does affect the brain. I was in touch with a doctor who studied the effect on mice and it clearly shows the effect on the brain. My son now nearly 6 years after taking this drug is left with joint pain, eye sensativity where he cannot look at TVs or mobile phone screen etc. He also has Tinitus ( ringing in his ears) . If he cannot sleep or has disturbed sleep he feels really ill the following day.