I am 38 year old female. have been taking spiro for a few months. I started at 25 mg and now take 25 mg twice a day. I have seen it help with my acne, but definitely not cure it. My derm had me up the dose another 25mg so 75mg all day. But just going up a little bit I felt like a zombie I could sleep all day. I was always tired and out of it. So I think everybody bodies are different and depends on your body and hormones if your dosage prescribed will have an effect. I was shocked that going up a little bit had such a huge negative side effect even though going up helped clear my acne better. And 75mg is considered a low dose according to my derm. Good luck!