Update: The last two articles I posted in my initial post were recently pulled from pubmed. I don't know why but I guess I can email Dr. Mann to find out.
However with regards to the second study below I can post
at least a dozen more linking various dietary changes, predominantly what the boys were following, and blood chemistry changes. These studies will cover both the
hormonal and
inflammatory markers that are
linked to acne just as in the study below and then some, but will be in relation to high cholesterol, obesity, diabetes, PCOS, Insulin Resistance and even Hyperandrogenism, most of which CAN have acne as a
symptom, but these studies will not specifically mention the word "acne".
QUOTE
Asia Pac J Clin Nutr. 2005;14 Suppl:S43. Related Articles, Links
The effect of a low glycemic load, high protein diet on hormonal markers of acne.Smith R, Mann N, Braue A, Varigos G.
School of Applied Sciences, RMIT University, Melbourne, VIC.
Background - Acne vulgaris is a common endocrine condition affecting adolescents in Western civilizations. Acne typically manifests during puberty when there is a transient decrease in insulin sensitivity. It has been suggested that high glycemic nutrition during puberty induces hyperinsulinemia which increases the bioavailability of androgens and certain growth factors. These changes may induce follicular epithelial growth and increased sebum production - two factors responsible for acne proliferation.
Objective - To determine the effect of a low glycemic load diet, comprised of high levels of protein and low glycemic index (GI) foods, on hormonal makers of acne vulgaris.
Design - Male acne sufferers [n=43, age=18.3+/-0.4 (mean +/- SEM)] were randomly assigned to either the dietary intervention (n=23) or control groups (n=20). The intervention diet consisted of 25% energy from protein and 45% energy from low glycemic index carbohydrates. The control group received no information about diet nor were they given dietary instruction. Venous blood was collected at baseline and 12-weeks for an assessment of
testosterone, sex hormone binding globulin
(SHBG), free androgen index
(FAI), dehydroepiandrosterone - sulfate
(DHEA-S), insulin-like growth factor
(IGF)-I and
IGF-binding proteins -I and -3. Outcomes - Dietary intervention resulted in a
significant reduction in FAI (-9.1 +/- 4.5, P<0.05) and DHEA-S (-0.72 +/- 0.33 umol/L, P<0.05) and an increase in IGFBP-1 (5.3 +/- 1.6 ng/mL, P<0.01). No significant changes were observed in levels of IGF-I, IGFBP-3, testosterone or SHBG following dietary intervention. The control group showed no change in any of the blood parameters measured.
Conclusion -
These data suggest that a low glycemic load diet may reduce androgenic activity (as indicated by a reduction in FAI and DHEA-S) and may oppose the growth promoting effects of IGF-I by increasing levels of its binding protein, IGFBP-I. This implies that a low glycemic load diet may reduce hormonal influences involved in acne pathogenesis.
http://www.ncbi.nlm.nih.gov/entrez/query.f...l=pubmed_docsum PMID: 16326495 [PubMed - in process]