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QUOTE
Asia Pac J Clin Nutr. 2004;13(Suppl):S67. Related Articles, Links
The effect of short-term altered macronutrient status on acne vulgaris and biochemical markers of insulin sensitivity.
Smith R, Mann N, Makelainen H, Braue A, Varigos G.
Food Science Department, RMIT University, VIC 3000.
Background - It has been suggested that a low-glycemic index diet may alleviate acne and this hypothesis is currently being investigated in a long-term dietary intervention study. A short-term, live-in study was designed to further investigate this link and to provide information on the short-term effects of altered macronutrient levels.
Objective - To determine the short-term effects of a low-glycemic load diet on markers of insulin sensitivity and how this relates to the clinical progression of acne vulgaris.
Design - Eleven male acne sufferers, aged 15-20, were allocated to either a high protein (HP,n=6, 40-45% energy from carbohydrate, 25% energy from protein) or high carbohydrate group (HC, n=5, 55-60% energy from carbohydrate, 10% energy from protein). Fat intake was maintained at 30-35% energy for each group. All meals were provided on an ad libitum basis for 7 days. Food consumed was measured at baseline and during the live-in study for an overall assessment of an individual's glycemic load. At baseline and day 7, the subject's acne was assessed by a dermatologist and blood was sampled for hormonal markers of acne and HOMA-IR.
Conclusion - The sample size and/or study length was insufficient to observe any significant changes in inflammatory counts or HOMA-IR in either the HP or HC groups. Although some results appear promising, further research is needed to confirm the diet-acne connection.
The effect of short-term altered macronutrient status on acne vulgaris and biochemical markers of insulin sensitivity.
Smith R, Mann N, Makelainen H, Braue A, Varigos G.
Food Science Department, RMIT University, VIC 3000.
Background - It has been suggested that a low-glycemic index diet may alleviate acne and this hypothesis is currently being investigated in a long-term dietary intervention study. A short-term, live-in study was designed to further investigate this link and to provide information on the short-term effects of altered macronutrient levels.
Objective - To determine the short-term effects of a low-glycemic load diet on markers of insulin sensitivity and how this relates to the clinical progression of acne vulgaris.
Design - Eleven male acne sufferers, aged 15-20, were allocated to either a high protein (HP,n=6, 40-45% energy from carbohydrate, 25% energy from protein) or high carbohydrate group (HC, n=5, 55-60% energy from carbohydrate, 10% energy from protein). Fat intake was maintained at 30-35% energy for each group. All meals were provided on an ad libitum basis for 7 days. Food consumed was measured at baseline and during the live-in study for an overall assessment of an individual's glycemic load. At baseline and day 7, the subject's acne was assessed by a dermatologist and blood was sampled for hormonal markers of acne and HOMA-IR.
Conclusion - The sample size and/or study length was insufficient to observe any significant changes in inflammatory counts or HOMA-IR in either the HP or HC groups. Although some results appear promising, further research is needed to confirm the diet-acne connection.
PMID: 15294556 [PubMed - in process]
Here's an update that was provided in March 2005 by a former mother member of ours (I so miss her):
QUOTE
Here's some excerpts from his emails when I questioned what the study was about:
**************
Minny talking:
I sent him an email telling him how much improvement I saw in my son's cystic acne from being on this for 1 month. He has one breakout on his cheek right now verses a whole face full prior to this diet. He is on NO medication.
Here's Dr. Mann's last email- he is reffering to my son's success.
QUOTE
--We are finding different people have different levels of sensitivity
but your sons diet of moderate level of carb foods and the type (most
sound low GI) should be very good. Look for low GI labelled foods and
get a book that lists GI of foods such as Jennie Brand-Miller's various
GI books, but there are many others. The brown rice is probably the
only thing you mention that could be still high GI (there are even
different types of brown rice) Our subjects ate limited amounts of
whole grain products and limited amounts of rice (low GI basmati) but no
high GI carb foods. I think whole grain low GI foods, should be OK
along with meats and fish (I doubt if the fat at this stage of life is
a worry for your son for acne, weight gain or heart disease, may be
later in life), in fact he may need extra fat and protein to provide him
more energy to make up for the decreased carbs. Certainly avoid sugary
sweet items like sweetened fruit juice and sodas and any product made
from flour or potatoes. Lots of vegetables, fruits and meat and fish
and nuts and beans, and soy. If he seems also sensitive to dairy as
some teenagers are then stay off dairy until acne phase is over.
--We are nearing completion of our study and will publish this year.
Slow process because we not only need to show an improvement in visual
acne condition but blood chemistry changes that can be used to develop
an hypothesis as to what aspects of metabolism are being altered by diet
to effect an acne change. This blood analytical work is happening now
and we are seeing complex metabolic changes that relate to various skin
cell abnormalities and acne. The dermatology side did show improvement
on our diet but I need to qualify this a little. Young boys do not
stick well on diets when they are free living and exposed to abundance
of processed foods. The boys on low glycaemic load diets did gradually
improve (4-8 weeks) if they kept to the diet which included:
Low starch and sugar intake, ie eliminate all high GI foods, which
eliminated most bread, potatoes, most rice, baked goods made from any
flour ie any refined carb product, some fruits also can have high carb
eg bananas so go easy on these, sweetened products with much added sugar,
glucose or corn syrup are very bad even fruit juices with added carb
sweeteners should be avoided.
Our diets were rich in meat, fish, vegetables, salads, most fruits,
nuts and very low in grain and sweetened foods.
The unfortunate part is that it takes several weeks to clear up the acne but only a day or
two to reactivate if a high GI carb food is consumed, this we cannot
alter, its just the way the metabolic process works, so the person must
be careful.
Finally we are not all genetically the same and your sons acne may not
respond to the same extent as others and there seem to be some rare
cases where the person has an intolerance to a particular food or food
group that stimulates acne for them individually, dairy is an example
for some people, so if the above does not work try food eliminations
over several weeks and try and identify any food group that he may be
reacting to.
but your sons diet of moderate level of carb foods and the type (most
sound low GI) should be very good. Look for low GI labelled foods and
get a book that lists GI of foods such as Jennie Brand-Miller's various
GI books, but there are many others. The brown rice is probably the
only thing you mention that could be still high GI (there are even
different types of brown rice) Our subjects ate limited amounts of
whole grain products and limited amounts of rice (low GI basmati) but no
high GI carb foods. I think whole grain low GI foods, should be OK
along with meats and fish (I doubt if the fat at this stage of life is
a worry for your son for acne, weight gain or heart disease, may be
later in life), in fact he may need extra fat and protein to provide him
more energy to make up for the decreased carbs. Certainly avoid sugary
sweet items like sweetened fruit juice and sodas and any product made
from flour or potatoes. Lots of vegetables, fruits and meat and fish
and nuts and beans, and soy. If he seems also sensitive to dairy as
some teenagers are then stay off dairy until acne phase is over.
--We are nearing completion of our study and will publish this year.
Slow process because we not only need to show an improvement in visual
acne condition but blood chemistry changes that can be used to develop
an hypothesis as to what aspects of metabolism are being altered by diet
to effect an acne change. This blood analytical work is happening now
and we are seeing complex metabolic changes that relate to various skin
cell abnormalities and acne. The dermatology side did show improvement
on our diet but I need to qualify this a little. Young boys do not
stick well on diets when they are free living and exposed to abundance
of processed foods. The boys on low glycaemic load diets did gradually
improve (4-8 weeks) if they kept to the diet which included:
Low starch and sugar intake, ie eliminate all high GI foods, which
eliminated most bread, potatoes, most rice, baked goods made from any
flour ie any refined carb product, some fruits also can have high carb
eg bananas so go easy on these, sweetened products with much added sugar,
glucose or corn syrup are very bad even fruit juices with added carb
sweeteners should be avoided.
Our diets were rich in meat, fish, vegetables, salads, most fruits,
nuts and very low in grain and sweetened foods.
The unfortunate part is that it takes several weeks to clear up the acne but only a day or
two to reactivate if a high GI carb food is consumed, this we cannot
alter, its just the way the metabolic process works, so the person must
be careful.
Finally we are not all genetically the same and your sons acne may not
respond to the same extent as others and there seem to be some rare
cases where the person has an intolerance to a particular food or food
group that stimulates acne for them individually, dairy is an example
for some people, so if the above does not work try food eliminations
over several weeks and try and identify any food group that he may be
reacting to.
**************
Minny talking:
I sent him an email telling him how much improvement I saw in my son's cystic acne from being on this for 1 month. He has one breakout on his cheek right now verses a whole face full prior to this diet. He is on NO medication.
Here's Dr. Mann's last email- he is reffering to my son's success.
QUOTE
--Very happy to hear this, fantastic for us researchers when we hear the
beneficial results of what we are working on, particularly when it does
not involve drugs.
Once we publish our study we will be talking at conferences in the USA
about it. I also hope to get print and TV media coverage so we can get
this knowledge out to millions of other young people and their families.
If you ever get an opportunity to present this information to media
particularly your US TV shows go for it and let me know. This is really
the best way to to communicate with the widest possible audience and as
you have seen the benefit can be outstanding.
My best wishes for your sons full recovery and his future.
http://www.acne.org/messageboard/index.php...opic=46037&st=0 beneficial results of what we are working on, particularly when it does
not involve drugs.
Once we publish our study we will be talking at conferences in the USA
about it. I also hope to get print and TV media coverage so we can get
this knowledge out to millions of other young people and their families.
If you ever get an opportunity to present this information to media
particularly your US TV shows go for it and let me know. This is really
the best way to to communicate with the widest possible audience and as
you have seen the benefit can be outstanding.
My best wishes for your sons full recovery and his future.
Apologies for the length, but for some reason I can't get these as individual posts!
QUOTE
Asia Pac J Clin Nutr. 2005;14 Suppl:S43. Related Articles, Links
The effect of a low glycemic load, high protein diet on hormonal markers of acne.
Smith R, Mann N, Braue A, Varigos G.
School of Applied Sciences, RMIT University, Melbourne, VIC.
Background - Acne vulgaris is a common endocrine condition affecting adolescents in Western civilizations. Acne typically manifests during puberty when there is a transient decrease in insulin sensitivity. It has been suggested that high glycemic nutrition during puberty induces hyperinsulinemia which increases the bioavailability of androgens and certain growth factors. These changes may induce follicular epithelial growth and increased sebum production - two factors responsible for acne proliferation.
Objective - To determine the effect of a low glycemic load diet, comprised of high levels of protein and low glycemic index (GI) foods, on hormonal makers of acne vulgaris.
Design - Male acne sufferers [n=43, age=18.3+/-0.4 (mean +/- SEM)] were randomly assigned to either the dietary intervention (n=23) or control groups (n=20). The intervention diet consisted of 25% energy from protein and 45% energy from low glycemic index carbohydrates. The control group received no information about diet nor were they given dietary instruction. Venous blood was collected at baseline and 12-weeks for an assessment of testosterone, sex hormone binding globulin (SHBG), free androgen index (FAI), dehydroepiandrosterone - sulfate (DHEA-S), insulin-like growth factor (IGF)-I and IGF-binding proteins -I and -3.
Outcomes - Dietary intervention resulted in a significant reduction in FAI (-9.1 +/- 4.5, P<0.05) and DHEA-S (-0.72 +/- 0.33 umol/L, P<0.05) and an increase in IGFBP-1 (5.3 +/- 1.6 ng/mL, P<0.01). No significant changes were observed in levels of IGF-I, IGFBP-3, testosterone or SHBG following dietary intervention. The control group showed no change in any of the blood parameters measured.
Conclusion - These data suggest that a low glycemic load diet may reduce androgenic activity (as indicated by a reduction in FAI and DHEA-S) and may oppose the growth promoting effects of IGF-I by increasing levels of its binding protein, IGFBP-I. This implies that a low glycemic load diet may reduce hormonal influences involved in acne pathogenesis. http://www.ncbi.nlm.nih.gov/entrez/query.f...l=pubmed_docsum
The effect of a low glycemic load, high protein diet on hormonal markers of acne.
Smith R, Mann N, Braue A, Varigos G.
School of Applied Sciences, RMIT University, Melbourne, VIC.
Background - Acne vulgaris is a common endocrine condition affecting adolescents in Western civilizations. Acne typically manifests during puberty when there is a transient decrease in insulin sensitivity. It has been suggested that high glycemic nutrition during puberty induces hyperinsulinemia which increases the bioavailability of androgens and certain growth factors. These changes may induce follicular epithelial growth and increased sebum production - two factors responsible for acne proliferation.
Objective - To determine the effect of a low glycemic load diet, comprised of high levels of protein and low glycemic index (GI) foods, on hormonal makers of acne vulgaris.
Design - Male acne sufferers [n=43, age=18.3+/-0.4 (mean +/- SEM)] were randomly assigned to either the dietary intervention (n=23) or control groups (n=20). The intervention diet consisted of 25% energy from protein and 45% energy from low glycemic index carbohydrates. The control group received no information about diet nor were they given dietary instruction. Venous blood was collected at baseline and 12-weeks for an assessment of testosterone, sex hormone binding globulin (SHBG), free androgen index (FAI), dehydroepiandrosterone - sulfate (DHEA-S), insulin-like growth factor (IGF)-I and IGF-binding proteins -I and -3.
Outcomes - Dietary intervention resulted in a significant reduction in FAI (-9.1 +/- 4.5, P<0.05) and DHEA-S (-0.72 +/- 0.33 umol/L, P<0.05) and an increase in IGFBP-1 (5.3 +/- 1.6 ng/mL, P<0.01). No significant changes were observed in levels of IGF-I, IGFBP-3, testosterone or SHBG following dietary intervention. The control group showed no change in any of the blood parameters measured.
Conclusion - These data suggest that a low glycemic load diet may reduce androgenic activity (as indicated by a reduction in FAI and DHEA-S) and may oppose the growth promoting effects of IGF-I by increasing levels of its binding protein, IGFBP-I. This implies that a low glycemic load diet may reduce hormonal influences involved in acne pathogenesis. http://www.ncbi.nlm.nih.gov/entrez/query.f...l=pubmed_docsum
PMID: 16326495 [PubMed - in process]
(yet another study linking dietary changes to affecting, thus altering our bodies hormonal production)
QUOTE
Asia Pac J Clin Nutr. 2005;14 Suppl:S97. Related Articles, Links
Low glycemic load, high protein diet lessens facial acne severity.
Smith R, Mann N, Braue A, Varigos G.
School of Applied Sciences, RMIT University, Melbourne, VIC.
Background - Acne vulgaris is a multi-factorial skin disorder which affects the 85-100% of the adolescent population in Western civilizations. Despite its high prevalence in the West, acne prevalence is extremely low or rare in non-westernized societies. It has been proposed that refined, high glycemic foods common in Western societies may accentuate underlying causal factors responsible for its proliferation.
Objective - To determine whether a low glycemic load diet, comprised of high levels of protein and low GI foods, can alleviate the severity of acne symptoms in young males Design - Male acne sufferers [n=43, age=18.3 +/- 0.4 (mean +/- SEM)] were randomly assigned to either the dietary intervention (n=23) or control groups (n=20). The intervention diet consisted of 25% energy from protein and 45% energy from low glycemic index carbohydrates. The control group received no information about diet nor were they given dietary instruction. The efficacy of dietary treatment versus control was clinically assessed by a dermatologist using a modified Cunliffe-Leeds acne scale. The dermatologist assessed facial acne by means of lesion counts and was blinded to the subject's group.
Outcomes - Dietary intervention resulted in a reduction in total lesion counts (-23.1 +/- 4.0 lesions, P <0.001) and inflammatory counts (-16.2 +/- 3.0 lesions, P <0.001). The control group also showed a reduction in total lesion counts (-12.0 +/- 3.5 lesions, P <0.01) and inflammatory counts (-7.4 +/- 2.5 lesions, P <0.05). However, between group analyses showed that the reduction was significantly greater in the intervention group for total counts (P <0.05) and inflammatory counts (P <0.05).
Conclusion - These data indicate that a low glycemic load diet, comprised of high levels of protein and low GI foods, significantly decreased the mean number of facial acne lesions, therefore alleviating the severity of acne symptoms. However, the multi-factorial nature of this condition is reflected in the fact that the control group also showed a decrease over time, thereby suggesting that other factors are at play. http://www.ncbi.nlm.nih.gov/entrez/query.f...l=pubmed_docsum
Low glycemic load, high protein diet lessens facial acne severity.
Smith R, Mann N, Braue A, Varigos G.
School of Applied Sciences, RMIT University, Melbourne, VIC.
Background - Acne vulgaris is a multi-factorial skin disorder which affects the 85-100% of the adolescent population in Western civilizations. Despite its high prevalence in the West, acne prevalence is extremely low or rare in non-westernized societies. It has been proposed that refined, high glycemic foods common in Western societies may accentuate underlying causal factors responsible for its proliferation.
Objective - To determine whether a low glycemic load diet, comprised of high levels of protein and low GI foods, can alleviate the severity of acne symptoms in young males Design - Male acne sufferers [n=43, age=18.3 +/- 0.4 (mean +/- SEM)] were randomly assigned to either the dietary intervention (n=23) or control groups (n=20). The intervention diet consisted of 25% energy from protein and 45% energy from low glycemic index carbohydrates. The control group received no information about diet nor were they given dietary instruction. The efficacy of dietary treatment versus control was clinically assessed by a dermatologist using a modified Cunliffe-Leeds acne scale. The dermatologist assessed facial acne by means of lesion counts and was blinded to the subject's group.
Outcomes - Dietary intervention resulted in a reduction in total lesion counts (-23.1 +/- 4.0 lesions, P <0.001) and inflammatory counts (-16.2 +/- 3.0 lesions, P <0.001). The control group also showed a reduction in total lesion counts (-12.0 +/- 3.5 lesions, P <0.01) and inflammatory counts (-7.4 +/- 2.5 lesions, P <0.05). However, between group analyses showed that the reduction was significantly greater in the intervention group for total counts (P <0.05) and inflammatory counts (P <0.05).
Conclusion - These data indicate that a low glycemic load diet, comprised of high levels of protein and low GI foods, significantly decreased the mean number of facial acne lesions, therefore alleviating the severity of acne symptoms. However, the multi-factorial nature of this condition is reflected in the fact that the control group also showed a decrease over time, thereby suggesting that other factors are at play. http://www.ncbi.nlm.nih.gov/entrez/query.f...l=pubmed_docsum
PMID: 16326597 [PubMed - in process]
