21 replies to this topic

[radikal]

@tritonxiv:
My take on the range of severities:

a) mild acne, acne vulgaris: may or may not be genetical, more likely not. It wouldn't make sense otherwise as upwards to 90% of teens are affected, it must be hormonal (DHT, etc)
b) adult acne (> 25y/o), cystic acne at any age - definitely genetic.
c) over-production of sebum - definitely genetic (just like with seborheea in Parkinson's).

[alternativista]

kidego, on 08 April 2012 - 11:31 AM, said:

My mother never had Acne but my father did. Genetics may play apart but I'm leaning towards only if both parents have the same Food Allergies.

Genetics definitely plays a part and not just about food intolerances. They are not the only factor that leads to acne formation. And I have come across multiple genetic factors involved in acne, such as genes involved in the metabolism of retinoids in our skin. I just don't have them all memorized or recall where I wrote them down. And I do not have a background in biology which would make it easier so assimilate such info. Some info is here: http://www.acne.org/...is-information/ and some scattered throughout the Good Things thread.

Also, no one in my mother's side of the family got acne. Not my cousins who are roughly my age, not my mother or her siblings, not my grandmother or her siblings, etc. All of my siblings and cousins on my fathers side did get acne. As did my father and his mother. And I don't know any more about that family.

These are things that are different in acne prone skin

-Deficiency in linoleic acid (applies to all kinds of skin conditions and to all kinds of animals)

-Fewer llamelar granulars that contain the desquammation enzymes and lipids (affected by the linoleic acid deficiency)

-More permeable around sebaceous glands and follicles (also about the linoleic acid)

-There are more estrogen receptors in skin of the acne prone, especially in males. http://www.ncbi.nlm....pt=AbstractPlus And this one which also suggests that the number of androgen receptors in skin play a role in acne prone people with normal serum levels http://www.ncbi.nlm..../pubmed/6448587

-More of the enzymes that convert androgens and estrogen (also affected by the linoleic acid deficiency)

-Deficient in retinoids, possible due to mutations in CYP26AI gene (that causes it to be metabolized too fast to be used?) See post below: http://www.acne.org/...is-information/ (probably also affected by the linoleic acid deficiency)

mystril, on 20 February 2012 - 02:08 PM, said:

true. whichever active enzymes inside any stuffs could potentially rendered inactive or destroyed with Stomach Acids.

He wasn't talking about enzymes in food. He was talking about those produced by your body. Enzymes are how genes perform whatever action they perform.

radikal, on 25 March 2012 - 10:13 AM, said:

I've been stricly controlling my diet and lifestyle for the last 12 years. It makes little to no difference. The seasons make more diference than diet (winter worse than summer).

Controlling your diet how? Limiting glycemic impact? Limiting anti-inflammatory foods? Determining any food intolerances?

How is it worse in winter? Melatonin affects cell proliferation so perhaps the altered melatonin cycle in winter is a factor.

Have you tried applying a linoleic acid source topically?

Edited by alternativista, 24 April 2012 - 09:11 AM.