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Successful human scar regeneration by topical iodine: a case report: an interim (3.5 year) summary.
Derry DM.
Control of regeneration and wound healing are scientific and clinical objectives. In 1997, topical Lugol's iodine solution applied daily for 3 days to a 50 year old facial scar lead to hyperemic scar tissue. As a working hypothesis, the author proposed topical iodine could initiate, control and complete human scar regeneration. In 2005, after collecting three more surgical scars, topical iodine applications began. Within 3 days all four scars started regenerating. Stopping topical iodine halted the process. Within a week an appropriate adult scar formed. Digital cameras recorded events. Regeneration is complex and slow. Its appearance depends on whether scar is covered with plastic or open. Iodine's chemical properties are discussed along with their reaction with epithelial cells. As there are no visible signs detectable changes from oral iodine on regeneration, details of iodine staining are more thoroughly described. Not all, but most important results are presented. Topical iodine induces hair growth in and around scars. Hair is regeneration's workhorse, moving purposefully in all directions under arrector pili muscle power delivering regenate material accurately to scar tissues and coordinating centers. In addition, hair repeatedly self amputates possibly strengthening regenerating tissues. Two types of regenate material show under plastic wrap: white and globular. The white regenate appears and behaves somewhat like snow, but can be yellow, green or brown depending iodine content. The globular form of regenate material maybe derived from white regenate material with hair's help. Globular regenate material is larger, nondescript, variable in size and color (depends on iodine content) and seemed usually associated with hair. There are two centrally placed coordinating centers 5 mm apart on major scars. Wrist centers have a palpable, but not visible ridge, between them whereas abdominal centers do not. Wrist centers lasted through all regeneration of the wrist scar, whereas abdominal centers were only present for about 18 months before falling off. This paper summarizes and adds to previous preliminary reports. The 50 year old scar regenerated completely 2 years ago. Small experiments on regeneration are possible because it is a slow process and more importantly can be stopped and started at will. These results support the proposed hypothesis topical iodine initiates, controls, and completes human scar regeneration.
PMID: 19168293 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov/pubmed/19168293
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Abstract: Since Spallanzini first described salamander limb regeneration in 1769, there has been slow progress in understanding this process. Potential treatment benefits from regeneration are worth the effort. A hypothesis that topical iodine would regenerate human scar tissue is tested by applying Lugol’s solution to four scars of various sizes, degree of damage, and location for variable lengths of time. Regeneration starts a few days after applying iodine and stops and forms adult scar if applications are discontinued. One face scar has completely regenerated. The wrist scar’s terminal stages are being studied. The remaining two scars on the abdomen are behaving as if they are one and could take considerably longer to complete. Waiting for completion delays availability of this information for scientists, physicians, and patients. For the past three years, Nikon Cool Pix cameras recorded regeneration changes. Regenate material found under plastic wraps on the scars comes in two forms, snow-like and globular. Their function is unknown. Two black dots both 5 mm apart seen on the wrist and abdominal scar store iodine and appear to coordinate regeneration. Hair is the regeneration workhorse and does an amazing number of things. Amongst the hair activities are free movement to any cell within its range in any direction and self-amputation possibly to strengthen regenerating tissue. Hair delivers regenate material and may be sending cell signals by touch, regenate material, and electrical impulses. The hypothesis that topical iodine in the form of Lugol’s solution regenerates human scar tissue back to normal is supported by these preliminary findings.
http://www.thyroidscience.com/cases/Derry....egen.6.7.08.pdf
Edited by scarcrash, 12 November 2009 - 12:42 PM.
Although I am not sure if hair grows in my atrophic regions. If it doesn;t and this forces hair growth through those regions then maybe I am onto something.
