Fukidia

This must go into the annals of "should-have-used-a-product-name-consultant":


Tokyo, Mar 17, 2006 (JCN) - On March 16, Kobayashi Pharmaceutical launched Fukidia, an over-the-counter (OTC) drug for alleviating adult acne.

The new ointment, which contains ibuprofen piconol as an active ingredient, helps suppress inflammation and prevent new pimples from forming.

One 10-gram unit sells for 1,000 yen (US $8.50).

Acne rosacea/demodex

Jessica,
I did a bit of online research last spring after someone here said his/her derm mentioned Demodex mites as a possible cause of his acneiform eruptions.

To show your hubby & make you feel better about those $100, here's a list of research papers I copied from a Rosacea site. The mites are implicated in the papulopustular form of Rosacea, the kind that looks very much like acne. The latest mite/Rosacea news is that the mites harbor a Gram negative bug of the bacillus genus (I've forgotten the exact name) that might be the actual irritant. The interesting thing about this is that the old sulfa drugs Bactrim and Septra, which many derms now consider the last resort/big guns before accutane, actually work best against Gram negative bugs.

I'll be reading your (and Queen's) journals with interest.

Quote
The clinical importance of demodex folliculorum presenting with nonspecific facial signs and symptoms.
Karincaoglu Y, Bayram N, Aycan O, Esrefoglu M.

In vitro and in vivo killing of ocular Demodex by tea tree oil.
Gao YY, Di Pascuale MA, Li W, Baradaran-Rafii A, Elizondo A, Kuo CL, Raju VK, Tseng SC. MD, PhD, Ocular Surface Center, 7000 SW 97 Avenue, Suite 213, Miami, FL 33173, USA. stseng@ocularsurface.com.

Topical application of 1-methylnicotinamide in the treatment of rosacea: a pilot study.
Wozniacka A, Wieczorkowska M, Gebicki J, Sysa-Jedrzejowska A.
Department of Dermatology, Medical University of Lodz, Poland. wozniacka@bmp.net.pl

Could matrix metalloproteinase-9 be a link between Demodex folliculorum and rosacea?
Bonamigo RR, Bakos L, Edelweiss M, Cartell A.


Density of Demodex folliculorum in perioral dermatitis.
Dolenc-Voljc M, Pohar M, Lunder T.
Department of Dermatovenereology, University Medical Centre Ljublana, Zaloska 2, SI-1525 Ljublana, Slovenia.

Demodecidosis in a patient infected by HIV: successful treatment with Ivermectin
Clyti E, Sayavong K, Chanthavisouk K.
Service de Dermatologie, Institut Guyanais de Dermatologie Tropicale, Hopital de Cayenne, Guyane Francaise.

The role of HLA A2 and Cw2 in the pathogenesis of human demodicosis.
Mumcuoglu KY, Akilov OE.
Department of Parasitology, Hebrew University-Hadassah Medical School, Jerusalem, Israel. kostam@cc.huji.ac.il

Demodicosis and rosacea: epidemiology and significance in daily dermatologic practice.
Forton F, Germaux MA, Brasseur T, De Liever A, Laporte M, Mathys C, Sass U, Stene JJ, Thibaut S, Tytgat M, Seys B.

Studies of di-n-butyl phthalate-OP emulsion in the treatment of demodicidosis
Xia H, Hu SF, Ma WJ, Ge JH.
Department of Microbiology and Parasitology, Bengbu Medical College, Bengbu 233003, China.

A clinico-pathological approach to the classification of human demodicosis.
Akilov OE, Butov YS, Mumcuoglu KY.
Department of Dermatology, Cosmetology Hospital "Aesthetics", Ekaterinburg, Russian Federation.

Efficiency of benzoyl peroxide-erythromycin gel in comparison with metronidazole gel in the treatment of acne rosacea.
Ozturkcan S, Ermertcan AT, Sahin MT, Afsar FS.
Department of Dermatology, Medical Faculty of Celal Bayar University, Manisa, Turkiye.

Rosacea: a clinicopathological approach.
Aroni K, Tsagroni E, Lazaris AC, Patsouris E, Agapitos E.
Department of Dermatopathology, School of Medicine, National and Kapodistrian University of Athens

Relationship between the Demodex and bacteria infection in human rosacea
Hu Q, Wang Y, Tong L.
Department of Parasitology, Medical college of Inner Mongolia National University, Tongliao 028041, China.

Facial demodicosis.
Zomorodian K, Geramishoar M, Saadat F, Tarazoie B, Norouzi M, Rezaie S.
Div. of Molecular Biology, Dept. of Medical Mycology & Parasitology, School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences, P.O. Box 14155, 64410 Tehran, Iran.

Immune response in demodicosis.
Akilov OE, Mumcuoglu KY.
Department of Dermatology, Cosmetology Hospital 'Aesthetics', Ekaterinburg, Russian Federation.

Treatment of human Demodex folliculorum by camphor oil and metronidazole.
El-Shazly AM, Hassan AA, Soliman M, Morsy GH, Morsy TA.
Departments of Parasitology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Demodex abscesses: clinical and therapeutic challenges.
Schaller M, Sander CA, Plewig G.
Department of Dermatology and Allergology, University of Munich, Germany

Eucalyptus globulus (camphor oil) in the treatment of human demodicidosis.
Morsy TA, Morsy GH, Sanad EM.
Department of Parasitology, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt

Association between human demodicosis and HLA class I.
Akilov OE, Mumcuoglu KY.
Department of Dermatology, Cosmetology Hospital Aesthetics, Ekaterinburg, Russian Federation.

The management of rosacea.
Rebora A.
Department of Endocrinological and Metabolic Diseases, Section of Dermatology, University of Genoa, Genoa, Italy.

Demodicidosis revisited.
Baima B, Sticherling M.
Department of Dermatology, University of Leipzig, Germany

Rosacea and the pilosebaceous follicle.
Powell FC.
Regional Centre of Dermatology, Mater Misercordiae Hospital, Dublin, Ireland

Rosacea: I. Etiology, pathogenesis, and subtype classification.
Crawford GH, Pelle MT, James WD.
Department of Dermatology, University of Pennsylvania Medical Center, USA.

Facial demodicosis.
Zomorodian K, Geramishoar M, Saadat F, Tarazoie B, Norouzi M, Rezaie S.
Div. of Molecular Biology, Dept. of Medical Mycology & Parasitology, School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences, P.O. Box 14155, 64410 Tehran, Iran.

Induction of rosaceiform dermatitis during treatment of facial inflammatory dermatoses with tacrolimus ointment.
Antille C, Saurat JH, Lubbe J.
Department of Dermatology, University Hospital, Geneva, Switzerland.

Is permethrin 5% cream effective for rosacea?
Swenor ME.
Harrisburg Family Practice, Residency Program, PinnacleHealth Hospitals, Pa, USA

Permethrin 5% cream versus metronidazole 0.75% gel for the treatment of papulopustular rosacea. A randomized double-blind placebo-controlled study.
Kocak M, Yagli S, Vahapoglu G, Eksioglu M.
Department of Dermatology, Kirikkale University, Faculty of Medicine, Kirikkale, Turkey.

Effects of intense pulsed light on sun-damaged human skin, routine, and ultrastructural analysis.
Prieto VG, Sadick NS, Lloreta J, Nicholson J, Shea CR.
Department of Pathology, UT-MD Anderson Cancer Center, Houston, Texas 77030, USA.

The pathogenesis of Demodex folliculorum (hair follicular mites) in females with and without rosacea.
el-Shazly AM, Ghaneum BM, Morsy TA, Aaty HE.
Department of Parasitology, Faculty of Medicine, Mansoura University, Egypt.

Increased density of Demodex folliculorum and evidence of delayed hypersensitivity reaction in subjects with papulopustular rosacea.
Georgala S, Katoulis AC, Kylafis GD, Koumantaki-Mathioudaki E, Georgala C, Aroni K.
National University of Athens, Department of Dermatology and Venereology, A. Sygros' Hospital, Greece

Rosacea-like demodicidosis associated with acquired immunodeficiency syndrome.
Jansen T, Kastner U, Kreuter A, Altmeyer P.
Department of Dermatology and Allergology, Ruhr-University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany.

Is demodex really non-pathogenic?
Pena GP, Andrade Filho JS.
Laboratorio Distrital Centro-Sul, Prefeitura de Belo Horizonte, Minas Gerais, Brasil

Rosacea, acne and other diseases of the seborrheic spectrum
Boni R.
Dermatologische Klinik, UniversitatsSpital Zurich.

Treatment of rosacea-like demodicidosis with oral ivermectin and topical permethrin cream.
Forstinger C, Kittler H, Binder M.
Department of Dermatology, Division of General Dermatology, University of Vienna Medical School, Austria

Limitations of standardized skin surface biopsy in measurement of the density of Demodex folliculorum. A case report.
Forton F, Song M.
Clinic of Dermatology, Universite Libre de Bruxelles, Saint Pierre University Hospital, Brussels, Belgium

Demodex mites in acne rosacea.
Roihu T, Kariniemi AL.
Department of Dermatology, Helsinki University Central Hospital, Finland.

Unilateral demodicidosis.
Pallotta S, Cianchini G, Martelloni E, Ferranti G, Girardelli CR, Di Lella G, Puddu P.
Department of Immunoderma-tology, Istituto Dermopatico Dell Imma-colata, IRCCS, Via dei Monti di Creta 104, 00167 Rome, Italy.

The significance of Demodex folliculorum density in rosacea.
Erbagci Z, Ozgoztasi O.
Department of Dermatology, Faculty of Medicine, Gaziantep University, Turkey.

A study on Demodex folliculorum in rosacea.
Abd-El-Al AM, Bayoumy AM, Abou Salem EA.
Department of Dermatology, Faculty of Medicine, Al-Azhar University, Nasr City, Cairo

Pilocarpine gel for the treatment of demodicosis--a case series.
Fulk GW, Murphy B, Robins MD.
College of Optometry, Northeastern State University, Tahlequah, Oklahoma, USA.

Rosacea-like demodicosis in an HIV-positive child.
Barrio J, Lecona M, Hernanz JM, Sanchez M, Gurbindo MD, Lazaro P, Barrio JL.
Dermatology, Service, Hospital General Universitario Gregorio Maranon, Madrid, Spain.

Demodicidosis or rosacea: what did we treat?
Hoekzema R, Hulsebosch HJ, Bos JD.
Department of Dermatology, Academisch Medisch Centrum, University of Amsterdam, The Netherlands.

Acne rosacea complicated with demodicosis
Bobrov VM.

Demodex mites in rosacea.
Diaz-Perez JL.


Rosacea
Decauchy F, Beauvais L, Meunier L, Meynadier J.
Service de dermatologie allergologie et photobiologie, hopital Saint-Charles, Montpellier.

The Demodex mite population in rosacea.
Bonnar E, Eustace P, Powell FC.
University Department of Ophthalmology, Mater Misercordiae Hospital, Dublin, Ireland.

Granulomatous rosacea associated with Demodex folliculorum.
Amichai B, Grunwald MH, Avinoach I, Halevy S.
Department of Dermatology, Soroka Medical Center of Kupat Holim, Beer-Sheva, Israel.

Rosacea: a study of clinical patterns, blood flow, and the role of Demodex folliculorum.
Sibenge S, Gawkrodger DJ.
Department of Dermatology, University of Sheffield, Royal Hallamshire Hospital, U.K.

The possible role of skin surface lipid in rosacea with epitheloid granulomas.
Basta-Juzbasic A, Marinovic T, Dobric I, Bolanca-Bumber S, Sencar J.
University Department of Dermatology, Medical Faculty, University of Zagreb, Croatia.

Topical steroid induced chronic demodicidosis.
Sakuntabhai A, Timpatanapong P.
Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

Rosacea: histopathologic study of 75 cases
Ramelet AA, Perroulaz G.
Service de dermatologie et de venereologie, CHUV, (Centre Hospitalier universitaire vaudois), Lausanne, Suisse.

The hair follicle mites (Demodex spp.). Could they be vectors of pathogenic microorganisms?
Wolf R, Ophir J, Avigad J, Lengy J, Krakowski A.
Department of Dermatology, Ichilov Medical Center, Tel-Aviv, Israel.

T-cell subsets in acne rosacea lesions and the possible role of Demodex folliculorum.
Rufli T, Buchner SA.


Ultrastructural study of demodex infestation of the face in healthy subjects and acne rosacea patients
Crosti C, Menni S, Piccinno R, Sala F.

Nosologic position of demodicidosis in humans
Bardach HG, Raff M, Poitschek C.

Demodicosis of ophthalmic concern.
English FP, Nutting WB.

Metronidazole and Demodex folliculorum.
Persi A, Rebora A.

Demodex folliculorum and rosacea: experimental and immunological studies
Grosshans E, Dungler T, Kien TT, Kremer M.

Perioral dermatitis--an allergic disease?
Arutjunow V.


Pyroglyphid mites, xerophilic fungi and allergenic activity in dust from hospital mattresses.
v d Lustgraaf B, Jorde W.

Pathogenesis associated with hair follicle mites (Demodex spp.) in Australian Aborigines.
Nutting WB, Green AC.

Demodecidosis and rosaceiform dermatitis
Hojyo Tomoka MT, Dominguez Soto L.

Demodex folliculorum in rosacea.
Ayers S Jr, Mihan R, Marks R, Harcourt-Webster JN.


The role of the acarid Demodex folliculorum in ophthalmology.
English FP.

The role of demodex mites in the development of acne rosacea
Kiselev OA.

Demodex folliculorum in patients with rosacea
Baksht BP.

Demodex folliculorum and rosacea. A clinical and histological study.
Robinson TW.


Demodectic eruptions (demodicidosis) in the human. 30 years' experience with 2 commonly unrecognized entities: pityriasis folliculorum (Demodex) and acne rosacea (Demodex type).
AYRES S Jr, AYRES S 3rd.

Rosacea: the role of demodex folliculorum.
BRODIE RC.

Rosacea and the pilosebaceous follicle.
Powell FC.
Regional Centre of Dermatology, Mater Misercordiae Hospital, Dublin, Ireland. 1974

Unquote


Feel better now? :-)

Licorice and testosterone

Thanks to Johan's posts below, I did some research on licorice and testosterone, and it looks like licorice (glycyrrhizic acid) may indeed lower testosterone levels in men and women--at least a little. For obvious reasons, guys might not want to mess with their testosterone levels but I thought those of feminine persuasion here might be interested in this study I found on Medline:




Anyone here try licorice?

P.S. A link to more info/research:
http://medherb.com/Materia_Medica/Glycyrrh...estosterone.htm