The first week I noticed a lot of the common side effects. Hoping it would help my PCOS like symptoms such as the excessive hair and mild/moderate acne right away, however, it did not. Which I knew, I just secretly wished I would be the rare case where I all of a sudden saw improvements. I experienced excessive thirst, insomnia, not too bad but in the middle of the night I would wake up for a good two hours not being able to go back to sleep. Thankfully netflix helped me with that issue. I also actually felt extremely tired about and hour or two after taking spiro. I also experienced headaches, but that was probably because of how little water I drank. I didn't see any dramatic changes, I just went through the side effects.