http://www.acne.org/messageboard/blog/6893-accutane-experience-recovery/ Accutane experience/ recovery Syndication Mon, 15 Apr 2013 21:37:28 +0000 webmaster@acne.org (Forums) IP.Blog 60 http://www.acne.org/messageboard/blog/6893/entry-26137-should-i-take-accutane-help/ Mon, 15 Apr 2013 21:34:55 +0000 http://www.acne.org/messageboard/blog/6893/entry-26137-should-i-take-accutane-help/ http://www.acne.org/messageboard/blog/6893/entry-26122-dont-stress/
If you've experienced side effects from accutane do not stress. I believe it makes them worse and there's a chance you might not be able to get out of a funk as is common with so many post tane users. I. E depression. It's a lot easier said than done, but you have to avoid it.

I went through a breakup and therefore went through extreme emotional stress. I'm turn this caused me to experience telogen effluvium on top of my already thinned hair from accutane. My facial flushing was exacerbated and skin went into remission. I have worse acne now because of the stress than I've ever had in my life. I've never had backne or really any body acne and now my shoulders chest and stomach are covered. And the healing sucks because of impaired healing after accutane.. Just do everything you possibly can to avoid stress

My skin got even thinner than it was and my premature wrinkles got even worse. I'm only 20. Firstly, don't take this drug I'd you haven't. Secondly even if you haven't, avoid prolonged stress. It's detrimental to your body]]> Sun, 14 Apr 2013 04:58:32 +0000 http://www.acne.org/messageboard/blog/6893/entry-26122-dont-stress/ http://www.acne.org/messageboard/blog/6893/entry-25911-skincare-vs-quality-of-life/ DON'T DO IT. 
 
There is so many things effed up about what this drug can do to you. Why take the chance? So you can have clear skin? There are many other options. Especially if you don't have SEVERE ACNE. And really look at yourself to determine if you have severe acne. I know that most, having acne, are already extremely self conscious about themselves and think it is the worst acne ever. Google severe cystic acne and if yours is not comparable to that than Accutane should not even cross your mind and your doctor should be sued for malpractice and pure fu**in stupidity. 
 
SOME SIDE EFFECTS ( In case you weren't already aware)
 

• Thinning hair
• Thinning of skin
• Facial flushing/ Rosacea
• Impaired wound healing (leads to easier scarring)
• Dry skin,mouth, nose, eyes
• Joint pain
• Depression
• Accelerated aging (Due to dry thin/fragile skin)
• Birth defects
• IBS
• Ulcerative colitis
• Other autoimmune diseases
  
• ​Raynauds syndrome
• Thyroid issues

​
These are just a few of the numerous lasting side effects. While those are only a few side effects, they are all side effects that would hack at the quality of your life. Please dont take accutane, it could ruin your life forever.
 
During my course of accutane (at 17 years old), the only side effect that i noticed was that my hair thinned, which to say the least was detrimental. I mean besides the notorious dry scaly skin and nosebleeds. I guess i also noticed i was more pale. Not until later, years later was i affected with other lasting side effects. Or maybe it was possibly that i had most of them all along and i didnt notice them until rosacea and fine lines at 19 years old came up that caused me to look at myself more carefully... Now looking back at pictures of myself before and right after accutane, i can see that my skin thinned, which it is supposed to do at first. My skin never regained its thickness nor did my hair.
 
And as to depression I don't think depression is a direct act of accutane. But if a severe emotional event comes upon one of post tane users i believe it makes it much harder and impossible for some to get out of that state of mind. Possibly due to the slowed or stopping of proliferation of certain cells in our minds or, idk. No one knows. No one with power cares enough to find out everything 13 cis retinoic acid (Accutane) does to the body. 
 
 
I wish i could go back in time and whoop my dermatologists ass for even thinking about prescribing me the drug for my mild acne as a first treatment.. I would of rather been locked in juvenile prison and had to of payed thousands in fines than have taken this drug. I don't know if there is anything i can really do besides look at myself slowly deteriorate. With my words i do however have the possibility to save the quality of your life and i really hope i can.
 
DON'T TAKE ACCUTANE IT CAN RUIN THE QUALITY OF YOUR LIFE FOREVER...
 
 ]]> Mon, 25 Mar 2013 05:16:00 +0000 http://www.acne.org/messageboard/blog/6893/entry-25911-skincare-vs-quality-of-life/ http://www.acne.org/messageboard/blog/6893/entry-25856-what-if-i-never-took-accutane/ Tue, 19 Mar 2013 05:48:40 +0000 http://www.acne.org/messageboard/blog/6893/entry-25856-what-if-i-never-took-accutane/ http://www.acne.org/messageboard/blog/6893/entry-25806-water-fast/
Also any opinions or advice welcome]]> Mon, 11 Mar 2013 05:31:35 +0000 http://www.acne.org/messageboard/blog/6893/entry-25806-water-fast/ http://www.acne.org/messageboard/blog/6893/entry-25756-accutane-and-depression/  
I was never depressed while on the drug. I mean i had some self esteem lows when my hair first thinned and walking through school with a dry irritated red face was somewhat embarrassing, but besides that i was fine. But now through looking at myself and learning something newer and even worse every day tears at me..]]> Mon, 04 Mar 2013 20:41:00 +0000 http://www.acne.org/messageboard/blog/6893/entry-25756-accutane-and-depression/ http://www.acne.org/messageboard/blog/6893/entry-25755-accutane-hairloss/  (Laying on the sarcasm as thick as butter used for a fat mans dinner roll). 
 
 
Where to begin.. First of all, i used to have a thick, thick head of hair that i would treat like a girl. I put the concoction of mayonnaise and eggs and such in there a couple times to make it soft and shimmery, (make fun of me, whatever haha)  i would only shampoo it every other day to maintain oils, and being a guy is obviously always cut regularly. 
 
Any who.. I think accutane works in many ways to contribute to hair loss and i don't have the time right now to compound and corroborate my information, but its on my mind so.. By shrinking sebaceous glands through apoptosis accutane makes the hair dry and brittle.  It also  increases your igfbp-3 (insulin growth factor binding protein) hormone which prevents IGF-1 from binding to the androgen receptors. It too is also possible that just the shock to your system from the drug can cause acute telogen effluvium which will be in the from of mass shedding that should come back in 6 to 9  months. I've also read things about vitamin d receptor sensitivity and fuction being messed with along with other hormones. My hair thinnned. Like the actual follicles thinned and they never returned .
 
Accutane is also known to mess with hormones in general and possibly related to hypo thyroid problems along with other things. If you have any concern, consult a doctor and express your concern and hopefully you can get tested to hopefully find a cure to your hairloss and maybe it wont just be solely accutane that caused it. 
 
I first suggest that you dont take accutane, but if you so choose then stop taking and report hair loss instantly to your dermatologist. 
 
I will be back to update and support information in this thread.
 
Lastly if you have experienced hair loss and/or know of any treatments/remedies/ cures for accutane induced hairloss please let me know. Thank you everybody]]> Mon, 04 Mar 2013 20:16:00 +0000 http://www.acne.org/messageboard/blog/6893/entry-25755-accutane-hairloss/ http://www.acne.org/messageboard/blog/6893/entry-25753-accutane-mechanism-of-action/  
 

• Report on how accutane could shorten telomeres

http://www.topix.com/forum/drug/accutane/T9QJ8DO1TLI41VBPN
 

• Possible epigenetic effects of accutane such as dna methylation of histone modification

http://askville.amazon.com/Medications-Accutane-risk-severe-side-effects/AnswerViewer.do?requestId=16222338
 

• Accutane regulates gene expression through FOX O

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219165/

• Gene changes

 
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835899/
 
 
 
I will probably be adding to this list, this is just a few of the possible explanations of accutanes mechanism of action on our body. From everything I have read and what i believe to be true is that Accutane does modify gene expression somehow. I have to believe that, because if it does not change anything permanently then wouldn't acne and oily skin just come right back after the treatment was completed. I also do believe that it can shorten telomeres, but i also believe that for all people this isnt permanent and telomerase enzyme is regulated back to normal after treatment. I do believe it permanently slows cell proliferation through apoptosis (programmed cell death) . I believe there is far too much cell death going on and lastly, i believe that not everyone will experience these side effects. Some people, i believe, are more genetically predisposed to experiencing these side effects just based upon their genome. ]]> Mon, 04 Mar 2013 19:05:00 +0000 http://www.acne.org/messageboard/blog/6893/entry-25753-accutane-mechanism-of-action/ http://www.acne.org/messageboard/blog/6893/entry-25752-accutane-for-scarring/ Mon, 04 Mar 2013 19:00:00 +0000 http://www.acne.org/messageboard/blog/6893/entry-25752-accutane-for-scarring/ http://www.acne.org/messageboard/blog/6893/entry-25751-life-after-accutane/ Mon, 04 Mar 2013 18:43:00 +0000 http://www.acne.org/messageboard/blog/6893/entry-25751-life-after-accutane/