Epiduo Adapalene (.1%) and Benzoyl Peroxide (2.5%) Gel reviews

Epiduo Adapalene (.1%) and Benzoyl Peroxide (2.5%) Gel
3.7/5 - 425 reviews
5 star
162 reviews
4 star
127 reviews
3 star
44 reviews
2 star
30 reviews
1 star
62 reviews
Epiduo Adapalene (.1%) and Benzoyl Peroxide (2.5%) Gel


Active Ingredients:
Adapalene (0.1%), Benzoyl Peroxide (2.5%).

Inactive Ingredients:
Acrylamide/sodium acryloyldimethyltaurate copolymer, docusate sodium, edetate disodium, glycerin, isohexadecane, poloxamer 124, polysorbate 80, propylene glycol, purified water, and sorbitan oleate.

The list of ingredients above is provided for informational purposes only. Always check the actual product label in your possession for the most accurate ingredient information due to product changes or upgrades that may not yet be reflected on our web site.

Epiduo Adapalene (.1%) and Benzoyl Peroxide (2.5%) Gel

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Epiduo Adapalene (.1%) and Benzoyl Peroxide (2.5%) Gel

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A miracle cream
Reviewed on May 17, 2015

Epiduo has been an absolute miracle. I have always suffered with acne on and off since 18, now 30 but for some reason over the last 6 months my skin has been at its very worst. As most sufferers of acne I too have spent hundreds of £s on so called spot killers; Proactive etc. These products just didn't work for me. So I finally bit the bullet and saw my GP who referred me to a Dermatologist who then prescribed me Epiduo. It does give a temporary burning/tingling feeling, but doesnt cause me any redness or irritation. Epiduo dries out the spots very well. My skins is still getting used to the cream but after only 2 weeks there has been major improvements. I use Epiduo along with Lymecycline tablets once a day. I hope the results continue. Only time will tell.

Great but grew immune - not a long term fix
Reviewed on May 15, 2015

I immediately started seeing results from using this for my hormonal moderate acne. I was using it combined with hormonal treatments. After 3 months by skin was perfectly clear! It was amazing! This clearest it has ever been. But unfortunately it only lasted about 2 months before my skin started to breakout again.... I think my skin just became immune to it and it no longer reacted to it. My doctor has now prescribed me Tretinoin and Clindamycin cream.. really hope this works!

It works! took 5 months but I don't have a single pimple
Reviewed on May 13, 2015

It really works, this product saved my skin. It took a long around 5 months for my skin to clear but it was worth it. I was getting huge painful cysts all over my chin (mainly hormonal acne) and it felt like every pore was clogged. I'd have 5+ active pimples most of the time, but I was scared to try accutane because of the risk of side effects. When I first tried Epiduo I applied too much and my skin burned and peeled and was incredibly painful. I gave up after a few days because of the pain, but decided to try it again. The second time I only used a THIRD of a pea sized amount for my chin and my upper lip, and even with this little amount it burned and peeled and sucked for around 3 months. (I was also on an oral antibiotic, so this may have helped with some of the healing) My skin SUCKED during the first two months; it was worse than it ever was and I was so discouraged. Epiduo literally pushes out everything from your skin, and seeing as all my pores were clogged, it caused so many pimples and whiteheads. It was a hard few months, but now my skin has heeled and all I'm left with is some red marks!! I don't have a single whitehead or pimple. I didn't see any results until the 4th month, so don't give up hope too soon! I recommend using a very mild cleanser and make sure you moisturize twice a day (I used cetaphil gentle cleanser and cetaphil heavy moisturizer)

Early stages
Reviewed on May 12, 2015

I've suffered from acne since I was in year 8 (13 yrs old), I am now 19. It's something that I really struggle with, I've found temporary solutions but nothing that has really stopped it in its tracks. I did have acne on my back, but when I went on the pill (birth control) that cleared it up, which led me to think it would do the same for my face, I was wrong. I went to my dermatologist in year 11 I think it was and he prescribed me epiduo, and told me that this was something to try before accutane, which I really did not want to go on. So I think I used it for a couple months, but I can't really remember what my reaction and results were from that time. I must have been lazy or forgot about using it. Reading all of these reviews now, I wish that I had stuck with it. Maybe then I wouldn't be in this situation.

Abit about my acne now:

My acne has been moderate, I get a lot on both of my cheeks and breakouts on my forehead, and when 1 goes away, another 2 come up. ( I am a culprit of picking pimples). They are usually little red with yellow heads a lot of the times in groups (lucky me). I've never had any cystic acne, so you guess that's where I am abit lucky. I wear makeup everyday, it's hard not to when your skin looks like mine.

This year I became fed up and decided to try epiduo again. Last week was the first time that I tried it, and I used it at night ( I know how much to use, from previous experience). So that night it didn't irritate my skin one bit, I was thinking maybe since I've used it before my skin might be used to it. The next morning when I woke up my spots had considerably gone down, obviously I wasn't expecting a miracle over night but that did give me some hope. The products I use in conjunction with the epiduo is the cetaphil gentle cleanser, witchazel toner and cetaphil moisturising cream. So the next few nights I repeated the process by only putting a thin layer over my problem areas and it was fine. After about 3 days of using it at nightly skin began to sting and was very inflamed, I knew that this was normal so I continued. It has been 1 and a half weeks nearly and my skin is very very dry. I'm not sure if I'm using enough moisturiser so tonight I might apply abit more than I usually do. But last night I noticed 2 pimples in a row on my cheek under the skin. I knew that they were going to make it to the surface and they did the next day.

I'm not sure if I'm going to leave out epiduo for tonight and continue tomorrow.

At the moment I am studying to be a beauty therapist, and my teacher has told me to stop the treatment for the duration of the course ( 1 year) because of the facials and waxing we do on the face. I really don't think it's an option for me, I've started now and i want to continue to get the best results. So I think I'm going to moisturise as much as possible and put on as little epiduo as I can.

I just wanted to document my journey with epiduo, and maybe in a month or more I will write another entry. I am very hopeful that this product will work, and I will try not to give up. Thank you everyone for writing there experiences and reviews, it has really given me some confidence in epiduo .

Please feel free to comment or anything to give me some tips/advice/maybe just to have a chat about your journey :)

by HANT on 05/12/2015 09:44
Hi, Do not stop using your Epi Duo. Dry, flakey, stingy and red skin is a normal symptom. I have suffered all. After a month on EpiDuo and another oral antibiotic I still have flakey skin but my skin has noticeably calmed down and I am just left with scarring (hope it stays this way) Don't skip days using Epi Duo. Continue on. I was also told by another skin specialist to discontinue use till skin calms down. I didn't stop; the pain was not nice but I rather go through that then have bad skin. Your skin will also be drier anyway due to the change in the weather. Maybe see if you can invest in a hydrating serum if your really worried about the dry skin.
by HANT on 05/12/2015 09:44
Hi, Do not stop using your Epi Duo. Dry, flakey, stingy and red skin is a normal symptom. I have suffered all. After a month on EpiDuo and another oral antibiotic I still have flakey skin but my skin has noticeably calmed down and I am just left with scarring (hope it stays this way) Don't skip days using Epi Duo. Continue on. I was also told by another skin specialist to discontinue use till skin calms down. I didn't stop; the pain was not nice but I rather go through that then have bad skin. Your skin will also be drier anyway due to the change in the weather. Maybe see if you can invest in a hydrating serum if your really worried about the dry skin.
1 In 100
Reviewed on May 10, 2015

Well I broke out horrible in 2014 it was so bad I cried when looking in the mirror I went to the doctor and they put me on Diane 35 it was amazing!!!! Within 3 months my acne was completely gone I was so happy I thought I could stop wearing makeup!!! But then it all tired bad I was vomiting I couldn't see so I went back to the doctors and turns out I'm allergic to one of the ingredients in birth control pills including Diane 35 so I had to be taken off it so now all my acne has come back. Yay! Not! So I've gone back to the doctor and they have out me on doxycycline antibiotics and epiduo cream but after first use of the cream the pain was unbearable my face was so painful and ichy!!! I then read the box and it said 1 in 10 people we have dry sore skin and 1 in 100 will have ichy skin!!! So not only am I allergic to the medication that works I'm also 1 in 100! So here I am still with a face full of acne crying every morning when I look in the mirror. Any other suggestions??? (16 years old)

PLEASE listen to your skin!
Reviewed on April 30, 2015

I used TactuPump for about 12 weeks and my skin was literally raw. I've never had such inflamed and terrible acne in my life. It was awful. I started out with just mild acne and after reading such positive reviews about TactuPump, I decided to give it a try. I regret it SO much. My jawline was especially bad. I couldn't look in the mirror for weeks. I went to the doctor and he told me to stop using it because my skin had a very bad reaction to it. I thought I could tough it out to see if it would get better, but it was just getting worse and worse every single day. I was very upset every morning, waking up seeing my acne getting worse. Even after stopping, the acne never got better. So I ended up with worse skin than when I started. Eventually, I went on Accutane (40g dosage) and that was only thing that cured my skin. Long story short, please please please listen to your skin. I kept waiting to see if it would get better, because reviews were saying that it was just your skin purging, but I really regret waiting that long before realizing that the product just wasn't fit for my skin. Terrible experience, but at the end of the day, I found a solution that cleared up the acne that TactuPump had brought out. This product may work for some, but unfortunately, it did not for me.

Life Saver
Reviewed on April 27, 2015

I have suffered from acne on and off since I was a teen and have tried lots of antibiotic treatments which worked and then stopped working, retin-a gel, benzoyl peroxide, salicylic acid etc. to the point where my Doctor said there was nothing more he could do as he had tried everything, I am now 39, and had a horrendous outbreak after having a few years of beautiful clear skin. I really thought I had grown out of acne, so was horrified when this happened.

I ordered Epiduo from an online UK registered pharmacy at a cost of £38 delivered after filling out a form, they have a doctor review before dispensing. I had not heard of this treatment before, and it was like a miracle cure. I had no irritation, redness nothing. Infact it was like putting a skin rejuvenation treatment on my skin. I must add, this might be due to the fact that before using this I had been using Benzoyl peroxide 10% cream, which I now realise was far too strong, this had probably toughened my skin up, so now Epiduo was like a walk in the park. I applied it once a night, and no more than that, following with Eucerin dry skin moisturiser 15 minutes afterwards, which is for really sensitive skin, I did not apply it more often, I was very disciplined, less is more.

My skin is now back to normal, and the spots cleared up within a week of starting to use it, I now have totally clear skin, lets hope it lasts. I would encourage everyone to give it a go.

Two Minds...
Reviewed on April 23, 2015


While holidaying in New York my skin broke out something chronic. I walked around the shops buying everything anyone would sell me, just to clear it up. It didn't work. It only got worse. Before you knew it, I was back to AUS with a horrible red-pimpley face. Just so you know; growing up I never really had acne, the odd hormonal pimple and thats about it. Well its been two years and I am now 24 and the battle is still going on. I have spent thousands of dollars on treatment - cosmetics, cosmeceuticals, peels, light therapies, doctor appts and now I am onto my pharmaceuticals.

My cosmetic doctor has given me a prescription for an oral antibiotic and this EpiDuo gel - he suggested using it with Rationale products.

So far - there are maybe slight improvements? But what I am STRUGGLING with most is the burning. I wash my face, apply hydration gel, epiduo and my face just BURNS!!!!? Is this normal? I have red inflamed and flaky areas on my face - this is my second week and I feel like I am really struggling. Can someone please tell me if there face feels like its on fire?!?

by Juaneeeeeee on 04/24/2015 02:41
Hi, I'm here to tell you that the burning sensation your having is normal! BP (Benzoyl Peroxide) tends burn for the first few weeks of application, but not to worry it will subside after a 3-4 weeks of application; your skin becomes used to it. Something that can help with the redness is NOT to scrub your face. Remember irritation=more acne, so scrubbing makes your skin more irritated leading to more break-outs. I would recommend you ordering the Acne.org regimen if you haven't yet. I've only been on it a week and I have seen some pretty good improvements! if you don't order it then try to go to a local pharmacy store and ask a worker for a non-clogging simple cleanser as well as a non-clogging moisturizer for your flakiness. And most importantly remember to not give up hope! Almost everyone in their lifetime will have acne so no matter how much you want to quit come on pushing through it. If your having trouble try to think about the reward that this will bring you cleared skin and a more happy you! Hope this helped and if you have any questions fell free to ask me:)
acne at my age????
Reviewed on April 22, 2015

Acne free all my life...til now! Developed acne about 15 months ago. ..started as tiny bumps on my chin...then bigger ones then them great big headless painful cystic kind...

tried every acne wash....cream...gel...mask peel etc....but all I was left with was dry sore red sun dried looking skin...

So decided to go docs...I got differin first which sort of helped tone the red acne down ...but didn't stop break outs! Also antibiotic didn't do much!

Went back to doc and got epiduo....heard this stuff had side effects like burning skin...drying you out...skin flaking so was worried but the weeks prior to going back to docs I'd changed how I looked after my skin...I'd got rid off all my acne washes and toners gels etc. ..and started using an oil cleanser and ph balanced face wash and aveeno moisturiser. ...my skin was really improving. ..was smoother and silky again...only one cystic spot which if had for ages....so using epiduo worried me after getting my skin soft again...but I wanted help with scarring and didn't want to break out again so I gave it a go!

After two weeks of using epiduo my skins ok...stings a bit on my skin for ten minutes but when it sinks in I pop my moisturiser over it (stings a bit again)...within a few days that huge cystic spot came to a head an popped!!! Yay....result...but two weeks on I've not had a single spot. ..no skin purging so far.....and acne scars have actually faded a good bit....no flaky skin or burnt red skin either..I actually believe this is down to using more ph balanced products which irritate are skin and dry it out loads causing are pores to produce more sebum and block pores causing more spots. ...also I think this aveeno cream is a miracle moisturiser as its the only one that never stung not even round my eyes. ..think thats helping lighten my scars too...never broke me out either...so oil cleanser first to remove dirt oils etc...then I use olay gentle face wash (gorgeous stuff and so much cheaper then acne ones)...then thin layer of epiduo over acne prone areas (not got any active acne but preventions better then cure)...let it sting and sink into my skin...then aveeno moisturise the area.... (I moisturise rest of face after washing leaving my chin and jaw for epiduo application. ..as you don't want to spread epiduo all over your healthy clear skin or near eyes)...

So far so good. ..I'd say use more ph balanced washes and creams etc. ..throw out anything that has salicylic acid or benzoyl peroxide in it...just use one acne treatment at a time so your not irritating acne more or damaging healthy skin!

Oh one last thing I use st Ives blemish control scrub (which has tiny bit of salicylic acid in it)...use it 1-3 times a week to buff off any rubbish....its amazing so can not part with this...alot more natural then other acne scrubs...

I actually look forward to putting on my make up now. ...all bumps have gone (just that cystic spot to really flatten out as even though it's healed they take ages to smooth out)....good luck to you. ..try this epiduo cream...anythings worth a shot when you have acne (as long as its off yer doc not out the drugstore);)

Reviewed on April 10, 2015

I started to grown severe acne last year. First, I tried Murad, which was absolutely a waste of money, didn't work at all and made my skin worse. Then i went to see a doctor, she first prescribed me Retin-A, I used it for 3 months, and didn't seem to work. Then she gave me Clindoxyl, it worked at the beginning, i got less break-out, but after 5 months, every time I use it, my face got burned, and became flaky, red, itchy, so I stopped, and it gave me scars! So I stopped. After that, my doctor said maybe go back to Retin-A, I said no. Then she gave me Differin, I didn't have any bad reaction, but it also didn't work, my acne came back, which is a total disaster.. Then, a dermatologist gave me this, I tried for two days, my face was on fire. so I listen to my pharmacist to put some moisturizer, but it became worse! My entire face was extremely painful! If you have sensitive skin, then run away from this product.

by Jmboseck23 on 04/29/2015 08:14
You might try applying some moisturizer and then applying TAZORAC GEL.... TAZORAC is a Rx similar to tretinoin, but seems to work much better!!! Good luck 😀